Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.

By A. Mantovani, S. Sozzani, M. Locati, P. Allavena, A. Sica. Trends in immunology, 2002

5,445 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/a73ef8c0d587a3f96ae499d2a12cadb049e51d1c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. Lisa M. Coussens
4. J. Pollard
5. P. Allavena
6. S. Gordon
7. F. Balkwill
8. F. Martínez

In Oncology

1. A. Mantovani
2. Lisa M. Coussens
3. A. Sica
4. J. Pollard
5. P. Allavena
6. S. Gordon
7. F. Balkwill
8. B. Ruffell

Citations in the corpus

• HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (2011, background): “Conversely, antitumoral and proinflammatory (i.e., M1-like) TAMs express higher levels of inflammatory and antiangiogenic cytokines such as IL-1, IL-6, Type I interferons (IFNs), IL-12, and CXCL9 (Mantovani et al., 2002).”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “studying their transcriptional profiling [2]; recent investiga-”
• Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. (2006, background): “Macrophages can respond to microenvironmental signals with distinct functional polarization programs, which regulate the influx of other immune cells, such as T lymphocytes, by producing a variety of cytokines and chemokines (Mantovani et al., 2002).”
• Macrophage activation and polarization. (2008, background): “Moreover, TAM express low levels of proinflammatory cytokines, such as IL-12, IL-1beta, TNFalpha, and IL-6 (11).”
• Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. (2007, background): “M2 macrophages, which produce high levels of arginase, favor tumor growth by enhancing angiogenesis, tissue repair, and tissue remodeling (57).”
• Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “of polarized immune responses [such as, Th1 and Th2, innate lymphoid cell (ILC) 1 and ILC2, type 1 and type 2 immunity] (10, 25, 31).”
• Macrophages, innate immunity and cancer: balance, tolerance, and diversity. (2010, background): “In response to IL-4 or IL-13, macrophages undergo alternative (M2) activation [10,27].”
• Repertoire of microglial and macrophage responses after spinal cord injury (2011, background): “Three different subsets of M2 macrophages (M2a, M2b and M2c) have been defined based initially on work on tumour”
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “Specifically, macrophages infiltrated in tumors are stimulated by tumor cells and T cell-derived cytokines such as IL-1 to induce a polarized M2 phenotype characterized by IL-4 and IL-10, etc.(302,303) IL-1β production induces CCL2 expression via inflammasome activation in TAMs and tumor cells as we”