MHC heterozygosity confers a selective advantage against multiple-strain infections

By D. Penn, Kristy Damjanovich, W. Potts. Proceedings of the National Academy of Sciences of the United States of America, 2002

615 citations recorded by the source corpus.

Subfields: Agronomy and Crop Science, Food Science, Immunology

View Paper: https://www.semanticscholar.org/paper/a72bee685d10e5dc1e97bfd622ccaaa2a2a5661d

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Citations in the corpus

Genetic quality and sexual selection: an integrated framework for good genes and compatible genes (2004, background): “genes found that these effects explained between 2% and 19% of the variation in fitness (Johnsen et al. 2000; Wedekind et al. 2001; Penn et al. 2002).”
How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings (2010, background): “Nonetheless, a number of studies have used this method, though few have detected a heterozygote excess (Paterson et al. 1998; Gutierrez-Espeleta et al. 2001; Penn et al. 2002; Seddon & Ellegren 2004; Oliver et al. 2009a).”
Major histocompatibility complex genes, symmetry, and body scent attractiveness in men and women (2003, background): “disease resistance (see Penn et al., 2002; Penn and Potts, 1999).”
Mate Choice and Genetic Quality: A Review of the Heterozygosity Theory (2007, background): “This may lead to an apparent heterozygote advantage in that the fitness of heterozygotes is greater than the average fitness of the homozygotes, but similar to the fitness of the homozygote that carries the resistance allele (Penn et al., 2002).”
MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years? (2003, background): “The MHC also comprises the most polymorphic genes in the vertebrate genomes, and many studies supported the general hypothesis that allelic diversity at MHC genes is maintained by parasitemediated balancing selection (Apanius et al., 1997; Edwards & Hedrick, 1998; Hughes & Yeager, 1998; Meyer & Thom”
The evolutionary ecology of the major histocompatibility complex (2006, background): “Penn et al (2002) showed that MHC heterozygote mice had greater survival and clearance capacity to avirulent Salmonella infections than homozygote mice.”
Female sticklebacks Gasterosteus aculeatus use self-reference to optimize MHC allele number during mate selection (2003, background): “A more diverse set of MHC alleles allows an individual to present a wider array of antigens to T cells and thus potentially to recognize a wider range of pathogens during early infection; e.g. MHC heterozygous mice are more resistant to multiple-strain infections (Penn et al. 2002).”
Genetic quality and offspring performance in Chinook salmon: implications for supportive breeding (2007, background): “Heterozygous individuals may have increased survivorship because they are able to present a broader array of antigens and thereby resist a broader array of pathogens (Doherty and Zinkernagel 1975; Penn et al. 2002; Kurtz et al. 2004).”
Genetic similarity of social mates predicts the level of extrapair paternity in splendid fairy-wrens (2005, positive): “…S IM IL A R IT Y A N D P A T E R N IT Y 9 5 1 regression analysis of the relationship between male characteristics and male reprodu deleterious effects of inbreeding depression (Keller & Waller 2002) and/or enhance offspring immune function (Johnsen et al. 2000; Penn et al. 2002; Reid et al. 2003).”
MHC-heterozygosity and human facial attractiveness (2005, result): “MHCheterozygote advantage in resistance to infectious diseases has been found in several recent studies, notably with regard to infections in mice by Salmonella and Listeria (Penn et al., 2002), and in humans by Hepatitis B (Thursz et al.”
The evolution of gene duplications: classifying and distinguishing between models (2010, background): “As a result, the maximum possible number of heterozygous individuals in the population is reache”
Rapid evolutionary dynamics and disease threats to biodiversity (2003, background): “resistant to multiple-strain bacterial infections than MHC homozygotes [ 92 ].”
The Evolution of Polyandry: Sperm Competition, Sperm Selection, and Offspring Viability (2005, background): “Females of a number of vertebrate species ranging from mice (Yamazaki et al. 1976) to humans (Wedekind et al. 1995) have been shown to prefer potential mating partners whose MHC haplotype would result in the production of MHC heterozygous offspring that are resistant to parasites (Penn et al. 2002).”
Kin recognition: an overview of conceptual issues, mechanisms and evolutionary theory (2010, background): “MHC-dependent mating preferences may function to increase or optimise offspring MHC-heterozygosity (e.g., Penn and Potts 1998, Penn et al. 2002), avoid inbreeding, or both (Penn 2002).”