MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?

By L. Bernatchez, Christian R. Landry. Journal of Evolutionary Biology, 2003

893 citations recorded by the source corpus.

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In Immunology

Citations in the corpus

A new theory of MHC evolution: beyond selection on the immune genes (2009, positive): “Several studies have compared the level of population divergence (FST or GST) based on the MHC and neutral microsatellite loci and found that both type of loci displayed surprisingly similar levels of genetic differentiation (Bernatchez & Landry 2003).”
The evolutionary ecology of the major histocompatibility complex (2006, background): “Indeed, Bernatchez and Landry (2003) reported a meta-analysis including 48 studies of which only one did not have an excess of nonsynonymous to synonymous substitutions. One disadvantage of using dN:dS is that the accumulation of high ratios may occur over large timescales (10 000–100 000 generation”
MHC-heterozygosity and human facial attractiveness (2005, background): “It is now well-established that MHC disassortative mating preferences exist in several species, with beneficial effects in terms of offspring heterozygosity ( Bernatchez & Landry, 2003; Jordan & Bruford, 1998; Penn & Potts, 1998), but the extent to which heterozygosity in mates plays a role in fema”
Genetic quality and offspring performance in Chinook salmon: implications for supportive breeding (2007, background): “In many populations, MHC loci are highly polymorphic and most individuals are heterozygous (Bernatchez and Landry 2003).”
The importance of immune gene variability (MHC) in evolutionary ecology and conservation (2005, background): “These diverse functions and characteristics place genes of the MHC among the best candidates for studies of mechanisms and significance of molecular adaptation in vertebrates [19,52,93].”
Ex situ conservation genetics: a review of molecular studies on the genetic consequences of captive breeding programmes for endangered animal species (2011, background): “For this purpose, non-neutral markers need to be studied, such as the major histocompatibility complex (MHC), which has been studied extensively in the wild (reviewed in Bernatchez and Landry 2003).”
Is There a Latitudinal Gradient in the Importance of Biotic Interactions (2009, background): “Several studies have linked MHC diversity to pathogen pressure (summarized in Bernatchez & Landry 2003), but few have explicitly examined the relationship between latitude and MHC diversity.”
The Developmental, Physiological, Neural, and Genetical Causes and Consequences of Frequency-Dependent Selection in the Wild (2006, background): “In the case of MHC molecules at Class I and II loci, there is a perfect physiological analogy between evolution of novel surface proteins that escape detection by the evolving host, and signaler and receiver evolution (Bernatchez & Landry 2003, Piertney & Oliver 2006).”
Passerine MHC: genetic variation and disease resistance in the wild (2007, background): “natural selection can promote local adaptation at the genetic level (Bernatchez and Landry 2003; Piertney and Oliver 2006).”
The effects of phenotypic plasticity and local adaptation on forecasts of species range shifts under climate change. (2014, result): “This scenario is supported by studies with plants (Savolainen et al. 2007; Leimu & Fischer 2008) and different vertebrates (Bernatchez & Landry 2003; Fischer et al. 2011).”
How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings (2010, background): “…much more difficult to identify and This journal is # 2010 The Royal Society differentiate between them empirically in wild populations, and so the key aim of determining the relative importance of the different mechanisms has remained elusive (Bernatchez & Landry 2003; Piertney & Oliver 2005).”
Single-Nucleotide Polymorphisms (SNPs) under Diversifying Selection Provide Increased Accuracy and Precision in Mixed-Stock Analyses of Sockeye Salmon from the Copper River, Alaska (2011, background): “One_MHC2_190 and One_MHC2_251 are located on genes responsible for the production of major histocompatibility complex (MHC) class II molecules associated with the immune system response in vertebrate organisms (Bernatchez and Landry 2003 ).”