The evolutionary ecology of the major histocompatibility complex

By S. Piertney, Matthew K. Oliver. Heredity, 2006

911 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Genetics

View Paper: https://www.semanticscholar.org/paper/fcea24f2a42e2cd4cf75274f28b9391a0cd4054a

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In Ecology, Evolution, Behavior and Systematics

In Genetics

Citations in the corpus

Is There a Latitudinal Gradient in the Importance of Biotic Interactions (2009, background): “MHC represents the highest expressed genetic diversity in humans and other vertebrates (Piertney & Oliver 2006) and is thought to result from balancing, frequency-dependent, and/or temporally or spatially variable selection imposed by pathogens (Hedrick 2002).”
Sneaking from a female perspective (2007, background): “…choose genetically compatible mates through olfactory cues based on MHC-specific odours (Jordan & Bruford 1998), and a substantial body of empirical evidence for major histocompatibility complex (MHC)-based mate choice has accumulated (see Neff & Pitcher 2005; Piertney & Oliver 2006 for review).”
How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings (2010, background): “…much more difficult to identify and This journal is # 2010 The Royal Society differentiate between them empirically in wild populations, and so the key aim of determining the relative importance of the different mechanisms has remained elusive (Bernatchez & Landry 2003; Piertney & Oliver 2005).”
MHC diversity in bottlenecked populations: a simulation model (2011, background): “This function seems to be the reason that the MHC genes are the most polymorphic vertebrate genes (Garrigan and Hedrick 2003; Sommer 2005; Piertney and Oliver 2006).”
A new theory of MHC evolution: beyond selection on the immune genes (2009, positive): “Takahata (1990) showed, however, that the topology of an allelic genealogy under balancing selection is similar to that of a neutral gene genealogy but with a different time scale.”
Mate Choice and Genetic Quality: A Review of the Heterozygosity Theory (2007, background): “Resistance against infectious disease is influenced by the major histocompatibility complex (Mhc), which is the most variable set of functional genes known in vertebrates (Piertney and Oliver, 2006).”
The Developmental, Physiological, Neural, and Genetical Causes and Consequences of Frequency-Dependent Selection in the Wild (2006, background): “In the case of MHC molecules at Class I and II loci, there is a perfect physiological analogy between evolution of novel surface proteins that escape detection by the evolving host, and signaler and receiver evolution (Bernatchez & Landry 2003, Piertney & Oliver 2006).”
Passerine MHC: genetic variation and disease resistance in the wild (2007, background): “It is likely that the MHC provides the best system available in vertebrates for investigating how natural selection can promote local adaptation at the genetic level (Bernatchez and Landry 2003; Piertney and Oliver 2006).”
Low S‐allele numbers limit mate availability, reduce seed set and skew fitness in small populations of a self‐incompatible plant (2010, background): “…at loci directly relevant to survival or reproduction such as the major histocompatibility (MHC) locus conferring disease resistance in vertebrates (Piertney & Oliver 2005), and the selfincompatibility (SI) locus (S-locus) in plants (Bateman 1954; De Nettancourt 1977), which can have an immediate…”
Genetic Polymorphism in Heterogeneous Environments: The Age of Genomics (2006, background): “The MHC genes are part of the immune system in vertebrates, and differential selection through resistance to pathogens is widely thought to be the basis of their high genetic variation (Edwards & Hedrick 1998, Hedrick & Kim 2000, Hughes 1999, Meyer & Thomson 2001, Piertney & Oliver 2006).”