Metals and neuroscience.

By Ashley I. Bush. Current Opinion in Chemical Biology, 2000

697 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Physiology

View Paper: https://www.semanticscholar.org/paper/a6ea79b4adbb23ff84bc7dd35f5f7461189303ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Nutrition and Dietetics

In Physiology

Citations in the corpus

Α-synuclein misfolding and Parkinson's disease. (2012, background): “While metal ions can cause brain damage directly [241–245], the”
Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease. (2003, neutral): “…study at a similar dosage (g/kg controls, although this is somewhat controversial (Reidbody weight) to that used in the previous transgenic erer et al., 1989; Jellinger et al., 1990; Dexter et al., APP study (Huang et al., 1999; Bush, 2000; Cherny et 1991; Jenner et al., 1992; Mann et al., 1994).”
Unfolding the role of protein misfolding in neurodegenerative diseases (2003, background): “Several of the proteins implicated in misfolding (including PrP, SOD1 and Aβ) can bind metal ions, indicating that a common mechanism of neurodegeneration might involve changes in metal ion homeostasi”
Copper in diseases and treatments, and copper‐based anticancer strategies (2009, background): “Moreover, there is now increasing evidence that, among others, altered metal homeostasis may be involved in the progression of neurodegenerative diseases.(10,11) Protein-metal interactions appear to play a critical role in protein aggregation and are therefore likely to provide a link between the ac”
Magnetic nanoparticles for theragnostics (2009, background): “As the abundant, redox-active metal, iron facilitates the generation of free radicals in the brain [116,117] and excess iron is associated with multiple neurodegenerative disorders, including multiple sclerosis, Alzheimer’s and Parkinson’s diseases [73].”
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options (2009, background): “Brain contains high level of fatty acids which are more susceptible to peroxidation, that consumes an inordinate fraction (20”
The metallobiology of Alzheimer's disease. (2003, background): “synaptic release is rapid and energy dependent, maintaining minimal basal levels in the interstitial spaces that are estimated to be ,500 nM (reviewed in Refs [26, 27 ]).”
Neurodegenerative diseases and oxidative stress (2004, background): “The brain is an organ that concentrates metal ions and recent evidence suggests that a breakdown in metal homeostasis is a key factor in a variety of age-related neurodegenerative disease”
Zinc and human health: an update (2011, positive): “Mounting evidence has demonstrated that aberrant zinc homeostasis is involved in the pathogenesis of AD (Atwood et al. 1999; Bush 2000; Maynard et al. 2005; Barnham and Bush 2008; Wang et al. 2010).”
Oxidative stress in neurodegenerative diseases (2012, background): “Superoxide can also react with ferric iron in the Haber-Weiss reaction leading to the production of Fe 2+ , which then again affects redox cycling [15] .”