Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.

By Sven Diederichs, D. Haber. Cell, 2007

709 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a6c077e452d3e4bd7c4445a9042f857bcfe9ce39

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Citations in the corpus

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship (2012, background): “Reduced Argonaute levels result in compromised regulation of miRNA targets and decreased miRNA levels as association with RISC promotes miRNA stabilit”
MicroRNA regulation by RNA-binding proteins and its implications for cancer (2011, background): “Occasionally, a processing intermediate is generated by AGO2-mediated cleavage of a pre-miRNA that probably facilitates removal of the passenger strand”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “In a second step, the RNase III endonuclease Dicer interacting with TARBP (TAR RNA binding protein) cleaves the precursor close to the terminal loop releasing RNA duplexes of 22 nucleotides (63).”
The many pathways of RNA degradation. (2009, background): “In both cases, a short (approximately 22 nt) single-stranded RNA is finally integrated into the RNA-induced silencing complex (RISC), which always includes a member of the Argonaut (Ago) protein family—the key mediators of miRNA function (see Diederichs and Haber, 2007).”
An overview of microRNAs (2015, neutral): “Other miRNAs may follow this same pathway[87].”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “This complex is the core of the RISC-loading complex [120].”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “Overexpression of each individual AGO family member enhances the abundance of mature miRNAs in HEK293 cell”
miR-24 inhibits cell proliferation by suppressing expression of E2F2, MYC and other cell cycle regulatory genes by binding to “seedless” 3′UTR microRNA recognition elements (2009, background): “identification of miRNAs is still unclear because Argonaute overexpression globally increases miRNA levels, perhaps obscuring the effect of an individual overexpressed miRNA (Diederichs and Haber, 2007).”