A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial…

By Lori A. Sturtz, K. Diekert, L. T. Jensen, R. Lill, V. Culotta. Journal of Biological Chemistry, 2001

712 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/a6a6cf8d158ad3ebb5ec4220429241e46c57a2fc

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In Molecular Biology

1. D. Tang
2. Xin Chen
3. D. Klionsky
4. Douglas C. Wallace
5. W. Moye-Rowley
6. Y. Bae
7. Hyunjin Oh
8. Young Do Yoo

In Neurology

1. D. Klionsky

In Physiology

1. D. Tang
2. D. Klionsky
3. S. Rhee
4. Douglas C. Wallace
5. N. Mizushima
6. Katherine R Parzych
7. Guido Kroemer
8. R. Scarpulla

Citations in the corpus

• Regulation of reactive oxygen species generation in cell signaling (2011, background): “chondrial matrix or by Cu, Zn-SOD in the IMS of mitochondria (Okado-Matsumoto and Fridovich, 2001; Sturtz et al., 2001; Weisiger and Fridovich, 1973a; 1973b).”
• Trends in oxidative aging theories. (2007, background): “CuZnSOD knockout CuZnSOD is the major cytoplasmic superoxide scavenger [180] and is also found in the mitochondrial intermembrane space [181,182].”
• The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae (2012, background): “While Sod1 is predominantly cytosolic, it also localizes to the mitochondrial inner membrane space where it is thought to function in the detoxification of superoxide generated from respiration (Sturtz et al. 2001).”
• A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Import of Cu/ZnSOD into the mitochondrial intermembrane space occurs as the apoprotein, which is metallated upon entrance into the intermembrane space by the CCS metallochaperone (166, 207).”
• Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, background): “O2− can be converted to nonradical derivatives such as hydrogen peroxide (H2O2) either spontaneously or catalyzed by superoxide dismutase (SOD) [9–13].”
• Copper metabolism in cell death and autophagy (2023, background): “This regulatory mechanism maintains the stability of ROS in the body and alleviates ROS generated by the electron transport chain (ETC), thereby avoiding the oxidant damage caused by copper overload [41].”
• Copper homeostasis and cuproptosis in health and disease (2022, background): “Both CCS and SOD1 are localized in both the cytoplasm and mitochondrial intermembrane space (IMS), where they detoxify mitochondria-derived superoxides.(39,40) In addition to delivering Cu to the secretory compartment and cytosolic proteins, Cu is targeted to the mitochondria, where cytochrome oxida”