Copper homeostasis and cuproptosis in health and disease
By Liyun Chen, J. Min, Fudi Wang. Signal Transduction and Targeted Therapy, 2022
1,283 citations recorded by the source corpus.
As an essential micronutrient, copper is required for a wide range of physiological processes in virtually all cell types. Because the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function, copper homeostasis is tightly regulated. Recent studies identified a novel copper-dependent form of cell death called cuproptosis, which is distinct from all other known pathways underlying cell death. Cuproptosis occurs via copper binding to lipoylated enzymes in the tricarboxylic acid (TCA) cycle, which leads to subsequent protein aggregation, proteotoxic stress, and ultimately cell death. Here, we summarize our current knowledge regarding copper metabolism, copper-related disease, the characteristics of cuproptosis, and the mechanisms that regulate cuproptosis. In addition, we discuss the implications of cuproptosis in the pathogenesis of various disease conditions, including Wilson’s disease, neurodegenerative diseases, and cancer, and we discuss the therapeutic potential of targeting cuproptosis.
Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics, Plant Science
View Paper: https://www.semanticscholar.org/paper/a289cfc19fe63abe0f37af74f265736f5305c2a9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Nutrition and Dietetics
In Plant Science
Citations in the corpus
- Copper metabolism in cell death and autophagy (2023, background): “The disorder of copper homeostasis can also go in the opposite direction, that is, copper overload, which will also endanger human health [15].”