Interconversion Between Intestinal Stem Cell Populations in Distinct Niches

By N. Takeda, Rajan Jain, M. Leboeuf, Qiaohong Wang, M. Lu, J. Epstein. Science, 2011

771 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a6a040abc5d7b2962a8d196a823d50c7665d8ac2

How researchers see this paper

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In Biomedical Engineering

1. Hans Clevers
2. S. Heilshorn

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Hongjun Song
4. Guo-li Ming
5. K. Loh
6. C. Kuo
7. Bruce J. Aronow
8. Howard L. Weiner

In Oncology

1. R. Nusse
2. Guo-li Ming
3. Hongjun Song
4. Hans Clevers
5. K. Loh
6. Pengfei Lu

Citations in the corpus

• The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations (2011, background): “This lineage relationship could possibly also be bidirectional with Lgr5 ISCs giving rise to Bmi1 ISCs, paralleling the Lgr5/Hopx bidirectional relationship (32), with superimposed regulatory mechanisms to control the total number of ISCs, to regulate the balance of active and quiescent ISCs within ”
• The Host Shapes the Gut Microbiota via Fecal microRNA (2016, positive): “We thus bred HopxERCre mice (Takeda et al., 2011) with Dicer1fl/fl mice to generate Dicer1DHopx (HopxERCreTg/ , Dicer1fl/fl; referred to as Dicer1DHopx hereafter) mice in which Hopx-expressing cells are deficient in miRNA following tamoxifen induction.”
• The pan-ErbB negative regulator, Lrig1, is an intestinal stem cell marker that functions as a tumor suppressor (2012, positive): “Using the metrics of proliferation, cell position and the reported cell number(s) per crypt (Barker et al., 2007; Montgomery et al., 2011; Sangiorgi and Capecchi, 2008; Takeda et al., 2011; Tian et al., 2011), we envision that Lrig1+ SCs are downstream from the more quiescent Bmi1+ or mTert+ SCs, an”
• Single-cell RNA-seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis (2015, methodology): “Hopx-CreER ;;mT/mGmice were generated by crossing HopxCreER f/+ (Takeda et al., 2011) [strain: Hopx/J, Jackson Labs Stock: 017606] with the mT/mG reporter line [strain: B6.”
• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “Yet, slowly cycling “reserve” +4 stem cells can be recalled to Lgr5 status (40) and vice versa (35).”
• The intestinal crypt, a prototype stem cell compartment. (2013, background): “Additional evidence indicated that the Hopx+ and Lgr5+ populations represent slow-cycling and fast-cycling stem cell populations that can interconvert (Takeda et al., 2011).”