Does nitric oxide modulate mitochondrial energy generation and apoptosis?

By S. Moncada, J. Erusalimsky. Nature reviews. Molecular cell biology, 2002

817 citations recorded by the source corpus.

Subfields: Biochemistry, Biophysics, Physiology

View Paper: https://www.semanticscholar.org/paper/a68272b24f8d3ba9e601c0e459d4b7c0a1acf4b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. E. Weitzberg
2. F. Larsen
3. B. Ekblom
4. M. Murphy
5. J. Lundberg
6. S. Snyder
7. Dean P. Jones
8. H. Sies

In Biophysics

1. M. Murphy
2. Dean P. Jones

In Physiology

1. E. Weitzberg
2. J. Lundberg
3. F. Larsen
4. B. Ekblom
5. M. Murphy
6. S. Snyder
7. Dean P. Jones
8. H. Sies

Citations in the corpus

• Redox compartmentalization in eukaryotic cells. (2008, background): “In addition to stimulation of mitochondrial NO production by calciumstimulated mtNOS activation, specific interaction of NO with cytochrome oxidase (complex IV) was shown to affect mitochondrial function [30].”
• Bcl-2-family proteins and the role of mitochondria in apoptosis. (2003, background): “Caspase-independent cell death can also be induced by direct effects on mitochondria, for example by ROS, nitric oxide [92] or other substances that are directly toxic to mitochondria [93].”
• The physiology and pathophysiology of nitric oxide in the brain. (2005, background): “, 1994) a regulation that can explain the existence of mtNOS (Moncada and Erusalimsky, 2002).”
• The discovery of nitric oxide and its role in vascular biology (2006, background): “This defect, which we have called metabolic hypoxia, might not be exclusive to septic shock but could also contribute to other inflammatory and degenerative conditions (Moncada & Erusalimsky, 2002).”
• Effects of dietary nitrate on oxygen cost during exercise (2007, background): “NO may also interact at other sites of the mitochondrial respiratory chain and in the Krebs cycle (for review, see Moncada & Erusalimsky 2002).”
• Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “During the aging process, myelin and neuronal loss occur, dendritic length and branching are decreased, and global brain volume is reduced.”
• S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding (2005, background): “Alternatively, NO combined with superoxide can form peroxynitrite, a powerful oxidant that promotes DNA breaks, lipid peroxidation and protein oxidatio”
• How mitochondria produce reactive oxygen species (2008, background): “As the apparent K m of cytochrome oxidase for O 2 is very low ( 1 μ M •− production [36–38].”