Redox compartmentalization in eukaryotic cells.

By Young-Mi Go, Dean P. Jones. Biochimica et Biophysica Acta, 2008

618 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cb16133001cb56fce8fdee80394028cb25e2f22b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Leslie B. Poole
2. M. Circu
3. T. Aw

In Molecular Biology

1. M. Krenz
2. Leslie B. Poole
3. M. Circu
4. Ronald J. Korthuis
5. Christopher P. Baines
6. W. E. Hennink
7. Theodore J Kalogeris
8. T. Aw

Citations in the corpus

• Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. (2011, background): “The intracellular level of GSH is also dependent on other redox couples such as NADH/NAD, NADPH/NADP and thioredoxinred/thioredoxinox [9,10].”
• The Basics of Thiols and Cysteines in Redox Biology and Chemistry (2014, background): “The redox “poise” (and direct targets of reductase activity) of Trx (oxidized and reduced forms) and GSH/GSSG redox pairs is different in many or all biological systems [85–87]; redox poise of these systems also varies greatly between different compartments of bacterial and eukaryotic cells [88].”
• Reduction-sensitive polymers and bioconjugates for biomedical applications. (2009, background): “GSH/GSSG is maintained at distinct, non-equilibrium potentials in mitochondria, cytoplasm, nuclei, the secretory pathway and the extracellular space [8].”
• Mitochondrial Energetics and Therapeutics (2010, neutral): “In the lysosome, the potential of the CyS/CySS redox control node is thought to play an important role in the lysosomal hydrolysis of cysteine-rich proteins containing disulfide bridges (152).”
• REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS (2010, positive): “The reader is referred to several excellent reviews by Jones and coworkers [43,44] and our recent review [25] for a more in-depth coverage of the concept of redox compartmentation in mammalian cells, non equilibrium thiol/disulfide redox systems and implications for redox signaling and regulation.”
• Cell Biology of Ischemia/Reperfusion Injury (2012, background): “…signaling specificity has not yet been attained, although a helpful explanatory hypothesis has recently been proposed by Jones and coworkers (Go and Jones, 2008), wherein the interaction of H2O2 with the aforementioned redox control nodes is compartmentalized into discrete, spatially and…”
• Ischemia/Reperfusion (2016, neutral): “disulfide forms on proteins that are compartmentalized allows H2O2 to participate in discrete, spatially and kinetically distinct signaling cascades (168,246,273,274,334,338,398,414).”