Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

By Suzanne M. Mandala, R. Hajdu, J. Bergstrom, E. Quackenbush, Jenny X. Xie, J. Milligan, R. Thornton, G. Shei, D. Card, C. Keohane and 6 more. Science, 2002

1,744 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a67fe5a3cd7a58f28d4f64576aed0a6c96e2d7b3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “Histology has shown that lymph node medullary sinuses of FTY720-treated mice are emptied of lymphocytes, which suggests that cells cannot access egress structure”
Regulation of Dendritic Cell Migration to the Draining Lymph Node (2003, neutral): “The fact that CCR7 / DCs, which are incapable of migrating to the lymph node, do not cause lymph node congestion indicates that this phenomenon is mediated by mature DCs that have reached the lymph node through mechanisms that still need to be identified but might be related to release of chemokines”
Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis (2010, background): “S1P concentrations are higher in body fluids and tissues than in lymphoid tissues, thus creating a gradient that drives egress of lymphocytes into the circulation.(38,40,60,63) The S1P levels in different tissues are maintained by the orchestrated activities of enzymes that regulate sphingolipid met”
The functional network of ion channels in T lymphocytes (2009, background): “In the presence of an S1P1 receptor agonist that mimics the action of FTY-720 in producing sequestration of lymphocytes within the lymph node, resulting in lymphopenia and a paucity of TEM cells in the periphery (273), two-photon imaging within the lymph node revealed lymphocytes logjammed adjacent ”
Biologically active sphingolipids in cancer pathogenesis and treatment (2004, background): “FTY720-P induces sequestration of lymphocytes in lymphoid tissues by acting as a high-affinity agonist for S1P receptor”
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network (2005, background): “5-fold increase in the plasma concentration of S1P in rodents promotes lymphoid-organ sequestration of lymphocytes and inhibits lymphocyte recirculation, and this response is rapidly reversed after cessation of the infusion of S1”