The many roles of chemokines and chemokine receptors in inflammation.

By I. Charo, R. Ransohoff. New England Journal of Medicine, 2006

2,608 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a649cddac6a221b683245efea82a6ee15b02ddbf

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Citations in the corpus

Monocyte recruitment during infection and inflammation (2011, background): “30 ), and these receptors bind to a variety of chemokines, including the shared ligands CCL3 (also known as MIP1α) and CCL5 (Ref”
Rejuvenation of regeneration in the aging central nervous system (2012, neutral): “Monocytes/macrophages are recruited from the circulation to sites of inflammation by chemotaxis in response to gradients of MCP-1, which binds the chemokine receptor CCR2 (Charo and Ransohoff, 2006).”
Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation (2009, background): “To respond to MCP-1/CCL2, cells need to express CCR2 (the cognate receptor for MCP-1/CCL2) (Charo and Ransohoff, 2006).”
Cytokines in Inflammatory Disease (2019, background): “depend on the targeted cell, making them pleiotropic [20].”
Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages (2009, background): “What is shared between these seemingly diverse clinical conditions is the role of inflammation in their pathogenesis [48].”
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease (2007, background): “Chemokines are chemotactic cytokines that bind specific G protein–coupled receptors on the surface of cells and mediate the accumulation of leukocytes at sites of inflammatio”
Therapeutic siRNA silencing in inflammatory monocytes (2011, background): “The production, recruitment and differentiation of monocytes, their subsets and their progeny have been studied in detai”
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. (2007, background): “RANTES is an important mediator of acute and chronic inflammation, with genetic evidence indicating its involvement in immunopathological disorders (Kim et al. 2004; Simeoni et al. 2004; Boger et al. 2005; Wang et al. 2005; Charo and Ransohoff 2006).”
Control of microglial neurotoxicity by the fractalkine receptor (2006, background): “Based on these and other findings, efforts to develop pharmacological inhibitors of CX3CR1 are in progres”
The role of inflammation in insulitis and β-cell loss in type 1 diabetes (2009, background): “Dialog between β cells and the immune system Chemokines are signal molecules that direct leukocyte migration and activation during the early stages of an innate immune response and contribute to the transition to adaptive immunity”