Histone lysine methylation: a signature for chromatin function.

By R. Sims, K. Nishioka, D. Reinberg. Trends in Genetics, 2003

718 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a5615dfc5484f495af254d5a432e7c294cc5721e

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Citations in the corpus

The SET-domain protein superfamily: protein lysine methyltransferases (2005, background): “Adapted from [54-56]; additional references listed in the table are those not cited in these reviews.”
Epigenetics: Definition, Mechanisms and Clinical Perspective (2009, background): “Although all acetylations of lysine residues on H3 and H4 have been associated with transcriptional activation (H3K9, H3K14, H3K18, H3K23, H4K5, H4K8, H4K12, and H4K16), methylation of lysine residues may be either associated with transcriptional repression (H3K9, H3K27, and H4K20) or activation (H3”
Elongation by RNA polymerase II: the short and long of it. (2004, background): “Silent or repressed regions co-map with methylation at the following histone lysine residues, H3-K9, H3-K27, and H4-K20, and transcriptionally active domains are typically associated with methylation at H3K4, H3-K36, and H3-K79 (Lachner et al. 2003; Sims et al. 2003).”
Vernalization requires epigenetic silencing of FLC by histone methylation (2004, methodology): “ChIP analysis on fca-1 plants, undertaken in at least three separate experiments, using antibodies specific to H3 dimethyl K9, H3 dimethyl K27 and H3 dimethyl K4 (a modification associated with active loc”
Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels (2019, background): “Histone methylation has complex functions; for example, H3K4, H3K36, and H3K79 promote gene transcription, whereas H3K9, H3K27, and H4K20 inhibit gene transcription [20,25].”
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. (2004, background): “Their catalytic activity resides in the evolutionarily conserved SET domain (Sims et al. 2003).”
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (2005, background): “In contrast, higher eukaryotes contain several H3 K4 methyltransferases with various specificities, a csuggesting a more complex picture for the regulation and function of H3 K4 methylation in higher eukaryotes t t(Sims et al., 2003).”
The interplay of histone modifications – writers that read (2015, neutral): “The interplay of histone modifications Tianyi Zhang et al In mammals, H3K4 methylation is catalyzed by six related homologs of the yeast SET1 — SETD1A, SETD1B, MLL1, MLL2, MLL3, and MLL4 [12].”
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. (2004, background): “Since the initial demonstration that the SET domain is required for the HMTase activity of SUV39H1 [22], several SET domain HMTases have been identiﬁed [3,5].”