Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors

By A. Pluen, Y. Boucher, S. Ramanujan, T. McKee, T. Gohongi, E. di Tomaso, E. Brown, Y. Izumi, R. B. Campbell, D. Berk and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2001

632 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/a56159778c0ac4868a86ad6ef21fc5ed355e3417

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Citations in the corpus

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors (2011, methodology): “Arafat HA, et al. (2007) Antihypertensives as novel antineoplastics: Angiotensin-Iconverting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma.”
Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor‐targeted drug delivery vectors (2006, neutral): “delivery systems Pluen et al. [2001]”
Dissecting tumour pathophysiology using intravital microscopy (2002, background): “As collagen is mostly produced by the host cells, and the host cells vary from one organ to the next, the diffusion coefficient in tumours is host-organ dependen”
Mechanisms of cancer drug resistance. (2002, background): “Host factors include poor absorption or rapid metabolism or excretion of a drug, resulting in low serum levels; poor tolerance to effects of a drug, especially in elderly patients, resulting in a need to reduce doses below optimal levels; inability to deliver a drug to the site of a tumor, as could ”
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited (2009, background): “Further, tissues devoid of interstitial collagen networks, e.g., the brain (Pluen et al., 2001), may well be traversed by tumor cells without necessitating proteolytic remodeling while still requiring ROCK-regulated molecular motors to squeeze a migrating cell through matrix openings smaller than…”
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation (2003, background): “jpg" NDATA ITEM> ]> Collagen content and structure are key determinants of macromolecular transport in tumor”
Nanomedicine: current status and future prospects (2005, background): “Distribution, organization and relative levels of collagen, decorin, and hyaluronan impede the diffusion of macromolecules and nanoparticles in tumors (117).”
Multistage nanoparticle delivery system for deep penetration into tumor tissue (2011, background): “After extravasation into tumor tissue, the nanoparticles shrink to 10 nm, significantly lowering their diffusional hindrance in the interstitial matrix (20) and allowing penetration into the tumor parenchyma.”
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “IIID), in turn influencing the uptake of therapeutic agents (104, 323, 365).”
Multidrug resistance in cancer: role of ATP–dependent transporters (2002, background): “Impaired drug delivery can result from poor absorption of orally administered drugs, increased drug metabolism or increased excretion, resulting in lower levels of drug in the blood and reduced diffusion of drugs from the blood into the tumour mas”