Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

By P. Bradford. Clinical Microbiology Reviews, 2001

2,973 citations recorded by the source corpus.

Subfields: Applied Microbiology and Biotechnology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/a55eb7cea785b0cf53c4da75a4d60cc7e16a3cc4

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In Applied Microbiology and Biotechnology

1. J. Pitout
2. P. Bradford
3. K. Bush
4. P. Nordmann
5. L. Poirel
6. 古谷 良輔
7. 山口 和将
8. Kevin B. Laupland

In Molecular Biology

1. L. Poirel
2. P. Nordmann
3. K. Bush
4. J. Pitout
5. 古谷 良輔
6. 山口 和将
7. Kevin B. Laupland
8. A. Carattoli

In Molecular Medicine

1. P. Nordmann
2. L. Poirel
3. J. Pitout
4. K. Bush
5. P. Bradford
6. A. Carattoli
7. R. Cantón
8. E. Dassa

Citations in the corpus

• Imipenem-EDTA Disk Method for Differentiation of Metallo-β-Lactamase-Producing Clinical Isolates of Pseudomonas spp. and Acinetobacter spp (2002, result): “However, occasional adjustment of the distance between the two disks is required to obtain optimal results (1, 7), as is the case with the double-disk test for the detection of extended-spectrum -lactamase-producing isolates (2).”
• Epidemiology of β-Lactamase-Producing Pathogens (2020, background): “Examples include the emergence of the first extended-spectrum -lactamase (ESBL), in which glycine was substituted for Ser238 in the SHV-1 -lactamase, resulting in SHV-2, which was resistant to expanded-spectrum cephalosporins (58, 59).”
• Clinical and Economic Impact of Common Multidrug-Resistant Gram-Negative Bacilli (2007, background): “The genes encoding the ESBLs are found on plasmids and have a great propensity to spread between bacteria (8).”
• Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. (2015, background): “BES-1, CME-1, VE-B-1, PER, SFO-1, and GES-1) (Bradford, 2001).”
• Acquired Antibiotic Resistance Genes: An Overview (2011, background): “In time the parent enzymes blaTEM-1, blaTEM-2, and blaSHV-1 have undergone amino acid substitutions (point mutations) evolving to the ESBLs, starting with blaTEM-3 and blaSHV-2 (Bradford, 2001).”
• Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. (2008, background): “Klebsiella species are intrinsically resistant to ampicillin and other aminopenicillins and can acquire resistance to cephalosporins and aztreonam by the production of extended-spectrum -lactamases (ESBLs) (51).”
• Emergence of Enterobacteriaceae producing extended-spectrum beta-lactamases (ESBLs) in the community. (2005, background): “Thus, very broad antibiotic resistance extending to multiple antibiotic classes is now a frequent characteristic of ESBL-producing enterobacterial isolates.(4) The majority of ESBL-producing organisms have been reported from hospitalized patients admitted to intensive care units (ICUs), but infectio”
• How to manage Pseudomonas aeruginosa infections (2018, neutral): “of hydrolysis to ceftazidime, cefepime and aztreonam [23,28].”