Acquired Antibiotic Resistance Genes: An Overview

By A. V. van Hoek, D. Mevius, B. Guerra, P. Mullany, A. Roberts, H. Aarts. Front. Microbio., 2011

1,072 citations recorded by the source corpus.

In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics. As this review is only dealing with acquired resistance, attention is also paid to mobile genetic elements such as plasmids, transposons, and integrons, which are associated with AR genes, and involved in the dispersal of antimicrobial determinants between different bacteria.

Subfields: Ecology, Molecular Medicine, Pollution

View Paper: https://www.semanticscholar.org/paper/36b6ae3ca12b10ec8633a05059360e24a8b9f7ec

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Citations in the corpus

• ARG-ANNOT, a New Bioinformatic Tool To Discover Antibiotic Resistance Genes in Bacterial Genomes (2013, background): “The sequence information for the AR genes was collected from different resources, and the information for 1,689 AR genes was included in the database (7, 9, 18, 20, 28).”
• Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements. (2017, background): “If an ARG is on 280 a conjugative or mobilizable plasmid, then this ARG has the potential to transfer among bacteria 281 (Bennett, 2008; van Hoek et al., 2011), so that resistance can spread throughout a given ecosystem.”