[Drug discovery and natural products: end of era or an endless frontier?].

By J. W. Li, J. Vederas. Biomeditsinskaia khimiia, 2011

767 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/a557e99c75b13879f49e1103c6759c2c8e0a1537

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Citations in the corpus

SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing (2012, background): “This represents the key bottleneck for various projects ranging from the Human Microbiome Project (HMP) (Gill et al., 2006) to antibiotics discovery (Li and Vederas, 2009).”
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery (2018, background): “The discovery of penicillin from fungus led to the screening of many microorganisms for potential antibiotics [29].”
The Natural Product Domain Seeker NaPDoS: A Phylogeny Based Bioinformatic Tool to Classify Secondary Metabolite Gene Diversity (2012, background): “Traditional natural product discovery paradigms have become increasingly inefficient [68] and are rapidly moving towards approaches that capitalize on access to DNA sequence data [69].”
BayesHammer: Bayesian clustering for error correction in single-cell sequencing (2012, background): “Existing metagenomic approaches (aimed at genes rather than genomes) are clearly limited for studies of such bacteria despite the fact that they represent the majority of species in such important studies as the Human Microbiome Project [4,5] or discovery of new antibiotics-producing bacteria [6].”
Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action (2012, background): “In spite of these successes over past decades, it has become clear that the drug discovery process has slowed down as the costs of bringing a drug to market have gone up tremendously (1).”
IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics (2017, background): “From this figure, it is seen that the majority of (8838) phytochemicals are found in less than 5 Indian medicinal plants while only a handful of (3) phytochemicals are found in more than 200 Indian medicinal plants.”
The Traditional Medicine and Modern Medicine from Natural Products (2016, background): “With time, those natural products have undergone interesting and meaningful developments in their ability to interact with numerous, varied biological targets, and some have become the most important drugs in health care system [14,22,23].”
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery (2011, background): “There is a renewed interest in natural products as sources for drug discovery (46).”
Virtual screening: an endless staircase? (2010, methodology): “, it will be worthwhile to couple such experimental techniques more closely with computer-based compound design and selectio”
Discovery and resupply of pharmacologically active plant-derived natural products: A review (2015, methodology): “…and analytical equipment, increasing number of targets available for testing, and improved possibilities for optimization of natural leads using synthetic modification strategies [reviewed in (Henrich and Beutler, 2013; Koehn and Carter, 2005; Li and Vederas, 2009; Paterson and Anderson, 2005)].”