In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling

By Simon J. Bulley, Alaa Droubi, J. Clarke, K. Anderson, L. Stephens, P. Hawkins, R. Irvine. 2016

30 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Lewis C. Cantley

In Immunology

1. Lewis C. Cantley

In Molecular Biology

1. Lewis C. Cantley
2. Nathanael S. Gray
3. David M. Sabatini
4. M. Laplante
5. M. V. Vander Heiden
6. J. Engelman
7. P. Pandolfi
8. Craig B. Thompson

Citations in the corpus

• Targeting the PI5P4K lipid kinase family in cancer using covalent inhibitors (2020, background): “However, PI5P4Kα was found to synthesize a pool of PI-4,5-P2 that is specifically important in mTORC2 regulation (Bulley et al., 2016) and to play a critical role in intracellular cholesterol transport by modulating PI-4,5-P2 homeostasis on peroxisome membranes (Hu et al., 2018).”