Salt formation to improve drug solubility.
By A. Serajuddin. Advanced Drug Delivery Reviews, 2007
1,399 citations recorded by the source corpus.
Subfields: Materials Chemistry, Pharmaceutical Science, Pharmacology
View Paper: https://www.semanticscholar.org/paper/a482f6f4b9615ba35aa6f6d9bc1e6af44a347fd9
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In Materials Chemistry
- Christopher J. H. Porter
- W. Charman
- S. Charman
- H. Williams
- R. Shanker
- Natalie L. Trevaskis
- Colin W. Pouton
In Pharmaceutical Science
- Christopher J. H. Porter
- W. Charman
- Natalie L. Trevaskis
- S. Charman
- H. Williams
- R. Shanker
- Colin W. Pouton
- D. McClements
In Pharmacology
- W. Charman
- Colin W. Pouton
- Christopher J. H. Porter
- S. Charman
- H. Williams
- R. Shanker
- Natalie L. Trevaskis
Citations in the corpus
- Strategies to Address Low Drug Solubility in Discovery and Development (2013, background): “…of pharmaceutical salts are attenuated, although significant increases in dissolution rate are still evident since the pH in the unstirred water layer reflects the pH of the dissolving salt rather than the bulk (buffered) pH (Serajuddin and Jarowski, 1985b; Li et al., 2005b; Serajuddin, 2007).”
- Insoluble drug delivery strategies: review of recent advances and business prospects (2015, neutral): “A pH-dependent solubility is exhibited by ionizable drugs, wherein weakly acidic drugs are more soluble at pH 4 p K a (ionization constant) and weakly basic drugs are soluble at pH o p K a 6 .”
- Advances in Oral Drug Delivery (2021, background): “the selection of optimal salt forms (Serajuddin, 2007; Vioglio et al., 2017)”