Advances in Oral Drug Delivery

By M. Alqahtani, Mohsin Kazi, Mohammad Alsenaidy, Muhammad Z. Ahmad. Frontiers in Pharmacology, 2021

700 citations recorded by the source corpus.

The oral route is the most common route for drug administration. It is the most preferred route, due to its advantages, such as non-invasiveness, patient compliance and convenience of drug administration. Various factors govern oral drug absorption including drug solubility, mucosal permeability, and stability in the gastrointestinal tract environment. Attempts to overcome these factors have focused on understanding the physicochemical, biochemical, metabolic and biological barriers which limit the overall drug bioavailability. Different pharmaceutical technologies and drug delivery systems including nanocarriers, micelles, cyclodextrins and lipid-based carriers have been explored to enhance oral drug absorption. To this end, this review will discuss the physiological, and pharmaceutical barriers influencing drug bioavailability for the oral route of administration, as well as the conventional and novel drug delivery strategies. The challenges and development aspects of pediatric formulations will also be addressed.

Subfields: Pediatrics, Perinatology and Child Health, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/79c877bc268eb0d24060ffc32382c1d817bf87de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

  1. J. O. Ogbodo
  2. Evaristus Chinonso Odoh
  3. S. C. Eze
  4. Ugochukwu Solomon Okpala
  5. Charles Chinkwere Okoroafor
  6. Ugochukwu Gideon Nwadike
  7. C. P. Nwike
  8. Ufedo Lovet Onoja

Citations in the corpus