Targeting inflammation in the treatment of type 2 diabetes: time to start

By M. Donath. Nature reviews. Drug discovery, 2014

675 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a47982636a696442bcdedee3a0f72f2842837ec8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Jamal Naderi
2. M. Longo
3. C. Miele
4. J. Petrie
5. G. A. Raciti
6. F. Beguinot
7. S. Maggini
8. T. Guzik

In Genetics

1. S. Maggini
2. A. Carr

In Molecular Biology

1. Hozumi Motohashi
2. Masayuki Yamamoto
3. Takafumi Suzuki
4. S. Maggini
5. Rhian M. Touyz
6. A. Carr
7. A. Dinkova-Kostova
8. Donna D. Zhang

Citations in the corpus

• Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases (2019, background): “At higher concentration, interleukin 1β induces the apoptosis of β cells by the NFκB pathway [62].”
• Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription (2016, background): “The binding of Pol II was upregulated in LPS-treated cells at the TSS of IL6 (2), the gene body of IL6 (3) and the TSS of the IL1b gene (5), similar to the TSS of the Nqo1 gene in LPSþDEM-treated cells used as a positive control (Nqo1 TSS).”
• Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes (2020, background): “The number of available drugs that can target different components of the immune system and improve different metabolic aspects is increasing rapidly (Donath, 2014).”
• Vitamin C and Immune Function (2017, background): “A major factor is persistent low-grade inflammation of adipose tissue in obese subjects, which plays a role in the progression to insulin resistance and type 2 diabetes, and which is not present in the adipose tissue of lean subjects [222,223].”
• Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms (2017, background): “The link between inflammation and T2D is further supported by genetic studies and clinical trials showing protective effects of immune-targeted therapies and anti-inflammatory actions of classic antidiabetes drugs.(64) Circulating and locally produced effector cytokines such as TNF-a, interferon-g, ”