Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

By M. Murphy, Robin A. J. Smith. Annual Review of Pharmacology and Toxicology, 2007

1,156 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/a3d5e9753e162d748909c8595d00806068d68556

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Rafael Radi
2. Dean P. Jones
3. Young-Mi Go
4. G. Ferrer-Sueta
5. P. Reddy
6. S. Dikalov
7. M. Jackson
8. S. Powers

In Organic Chemistry

1. Dean P. Jones
2. Young-Mi Go
3. S. Dikalov
4. M. Jackson
5. S. Powers
6. M. Murphy

Citations in the corpus

• Redox compartmentalization in eukaryotic cells. (2008, methodology): “The approaches have been complemented by techniques to measure redox potential in living cells, largely based upon partitioning of lipophilic cationic fluorescent chemicals into mitochondria dependent upon the high mitochondrial membrane potential (Δψ) [6] and development of redox-sensitive forms of”
• Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait (2010, neutral): “or small molecules conjugated to lipophilic cation”
• Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. (2009, background): “Molecules that react with and decompose peroxynitrite or peroxynitrite-derived radicals that can be directed to specific subcellular compartments where peroxynitrite is formed, such as mitochondria, can be a valid strategy in diseases where organelle dysfunction secondary to peroxynitrite formation ”
• Therapeutics of Alzheimer's disease: Past, present and future. (2014, background): “MitoQ selectively accumulates in the organelle, continually recycled by mitochondrial enzymes, and it can function even in the absence of an intact ETC, which makes it a potent antioxidant compared to the untargeted ones (Murphy and Smith, 2007).”
• Mitochondrial Energetics and Therapeutics (2010, neutral): “This approach has proven promising in modelsystem studies (259, 260).”
• Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production (2008, background): “For example, using a mitochondrial targeted antioxidant, researchers could study specific mitochondrial ROS production and its consequences using organelle specific antioxidants (5, 57, 274, 369).”
• Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) (2011, background): “Mitoquinone (MitoQ), a coenzyme Q10 analogue that acts as a ROS scavenger, contains a lipophilic triphenylphosphonium cation that causes the antioxidant to accumulate several hundredfold within mitochondria because of the high mitochondrial membrane potential (Murphy and Smith, 2007; Villalba et al.”
• Crosstalk between mitochondria and NADPH oxidases (2011, background): “For example, previously described mitoquinone (MitoQ10) [78] may have pro-oxidant and proapoptotic properties due to redox cycling and generation of O2 by quinone [79,80].”
• Mitochondrial dysfunction and oxidative stress in metabolic disorders - A Step towards mitochondria based therapeutic strategies (2016, background): “pass through the lipid bilayers and accumulate 100 to 1000-fold within mitochondria [230,231].”
• How mitochondria produce reactive oxygen species (2008, background): “This raises the possibility that better understanding of how mitochondria produce ROS will lead to the rational design of therapies to minimize mitochondrial oxidative damage [130].”