An ecological and evolutionary perspective on human–microbe mutualism and disease

By Les Dethlefsen, M. McFall-Ngai, David A. Relman. Nature, 2007

1,633 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/a3b09b4e953b81e1fb6c758f34107bb250c56e51

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Citations in the corpus

Microbiota regulates immune defense against respiratory tract influenza A virus infection (2011, background): “The phyla Firmicutes (Gram positive) and Bacteroidetes (anaerobic Gram negative) are predominant in the human colon (44), whereas aerobes (facultative anaerobes), such as Escherichia, Enterobacter, Enterococcus, Klebsiella, Lactobacillus, and Proteus, remain a small minority (43).”
Worlds within worlds: evolution of the vertebrate gut microbiota (2008, background): “This leads to the question of what types of selective pressures act on these diverse lineages of gut microorganisms to drive them to differentiate into gut and non-gut groups? Selection forces and gut microbiota The ecological and evolutionary forces that are thought to be important in shaping t”
From Animalcules to an Ecosystem: Application of Ecological Concepts to the Human Microbiome (2012, background): “We recognize that ours is not the first attempt to delve into the ecology of the human microbiome; there are a number of excellent reviews on the topic (e.g., Dethlefsen et al. 2007, Gonzalez et al. 2011, Robinson et al. 2010).”
Intestinal microbiota in functional bowel disorders: a Rome foundation report (2012, background): “The microbiota is taxonomically classified via the traditional biological nomenclature (phylumdclassdorderd familydgenusdspecies) and currently more than 50 bacterial phyla have been described, of which 10 inhabit the colon and three predominate: the Firmicutes, Bacteroidetes and the Actinobacteria;”
The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women (2014, background): “Therefore, studies of the microbiota in several body sites are characterizing stability and resilience, as well as how they relate to health and disease [221-233].”
Exploring Microbial Diversity and Taxonomy Using SSU rRNA Hypervariable Tag Sequencing (2008, background): “For example, some health benefits are associated with only certain strains of probiotic species in the human gut [30].”
Temporal and spatial variation of the human microbiota during pregnancy (2015, background): “The microbiota plays critical roles in health and in disease, including nutrient acquisition, immune programming, and protection from pathogens (3).”
Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota (2012, background): “The HMb is similar to the microbiotas of other mammals at the phylum level but distinct at the species and strain levels (Dethlefsen et al., 2007).”
Interaction between microbiota and immunity in health and disease (2020, background): “From an ecological perspective, mammals and their commensal microorganisms co-evolved toward mutualism and hemostasis.(5) Such intimate relationship requires the proper functioning of host immunity to prevent commensals from overexploitation of host resources while maintaining immune tolerance to in”
Gut microbiome dysbiosis and honeybee health (2011, background): “…these evidences and according to a recent review examining the complex evolutionary and ecological mechanisms governing human symbiotic communities (Dethlefsen et al. 2007), it is important to underline the following for a better understanding of the host-microbiome relationship, it is not enough…”
The Pervasive Effects of an Antibiotic on the Human Gut Microbiota, as Revealed by Deep 16S rRNA Sequencing (2008, background): “The most striking features of Figure 4 are consistent with our current understanding of the human distal gut microbiota [1,2,29,30]: (1) Most members of the community belong to a small number of genera within the Bacteroidetes and Firmicutes phyla, with members of Proteobacteria and Actinobacteria o”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Variation, selection, (or drift, see below), and evolution within the holobiont can occur individually in all participants of the holobiont, namely, in the host as well as in the individual microorganisms (West et al. 2006; Dethlefsen et al 2007).”
Disordered Microbial Communities in Asthmatic Airways (2010, background): “Ecological changes altering this symbiosis can result in disease [17].”