Ceramide in apoptosis: an overview and current perspectives.

By B. Pettus, C. Chalfant, Yusuf A. Hannun. 2002

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Mammalian Ceramide Synthases (2010, background): “SLs is ceramide, which has received wide attention over the past couple of decades because of its proposed role as an important intracellular signaling molecule involved in regulating differentiation, proliferation, and apoptosis (1, 2).”
Biologically active sphingolipids in cancer pathogenesis and treatment (2004, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7124">TNFα ), growth factor withdrawal, hypoxia, hyperthermia and DNA damag”
Identification of a family of animal sphingomyelin synthases (2004, background): “The latter two are important regulators of membrane trafficking, cell proliferation and apoptosis (Kolesnick and Hannun, 1999; Bankaitis, 2002; Brose and Rosenmund, 2002; Pettus et al, 2002).”
Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “Many of these mediators of apoptosis are regulators of ceramide generation, suggesting a role for ceramide in apoptosis (Pettus et al., 2002).”
Mitochondrial Ceramide and the Induction of Apoptosis (2005, neutral): “1(a) and Pettus et al., 2002).”
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. (2010, background): “While mitogenic signaling pathways have been implicated inmaintaining high levels of Bcl-x(L), a proapoptotic pathway initiated by the sphingolipid ceramide has been suggested to promote Bcl-x(s) splicing (Chalfant et al. 2002; Pettus et al. 2002).”