Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

By Toshiaki Watanabe, Y. Totoki, A. Toyoda, M. Kaneda, Satomi Kuramochi‐Miyagawa, Y. Obata, H. Chiba, Yuji Kohara, T. Kono, T. Nakano and 3 more. Nature, 2008

1,181 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/a34399cdac4f0dc33895fda885b07d7335a31976

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In Cancer Research

1. David P. Bartel
2. John S. Mattick
3. V. Narry Kim
4. Eric C. Lai
5. Gregory J. Hannon
6. Marcel E. Dinger
7. M. Siomi
8. J. Ruby

In Molecular Biology

1. David P. Bartel
2. John S. Mattick
3. V. Narry Kim
4. M. Siomi
5. Gregory J. Hannon
6. Marcel E. Dinger
7. Eric C. Lai
8. J. Ruby

In Plant Science

1. David P. Bartel
2. John S. Mattick
3. M. Siomi
4. Gregory J. Hannon
5. V. Narry Kim
6. J. Goodier
7. Haig H. Kazazian
8. Eric C. Lai

Citations in the corpus

• Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. (2010, background): “…mice, similar precursors are found in the form of hairpin siRNA (hp-siRNA) precursors, but their expression appears to be limited to germline tissues and totipotent ES cells, which lack a robust interferon response to intracellular dsRNA (Babiarz et al. 2008; Tam et al. 2008; Watanabe et al. 2008).”
• Annotating non-coding regions of the genome (2010, background): “In these cases, the antisense transcript from the pseudogene binds to the mRNA of its parent, generating a natural endogenous small interfering RN”
• Long Noncoding RNAs: Past, Present, and Future (2013, background): “…of endo-siRNAs have been found in mammalian germ cells that are produced from the complementarily basepaired regions between coding and/or noncoding SAS pairs, between mRNAs and expressed pseudogenes, or from within pseudogenes containing inverted repeats (Tam et al. 2008; Watanabe et al. 2008).”
• Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (2008, background): “A similar hp-siRNA biogenesis pathway has been reported in mouse oocytes (Tam et al. 2008; Watanabe et al. 2008) and in Drosophila (Czech et al. 2008; Ghildiyal et al. 2008; Kawamura et al. 2008; Okamura et al. 2008).”
• PIWI-interacting small RNAs: the vanguard of genome defence (2011, background): “and, in mice, endo-siRNAs also target TEs in the female germ lin”
• Biogenesis of small RNAs in animals (2009, background): “endo-siRNAs have been studied mostly in Drosophila melanogaster , although they have also been found in mouse oocytes and embryonic stem (ES) cell”
• microRNAs in action: biogenesis, function and regulation (2023, background): “Indeed, mouse oocytes are a unique mammalian setting where siRNAs are not only abundant and functional 164,165 but may play a dominant regulatory role instead of miRNAs or piwi-interacting RNAs 166–168 .”