Annotating non-coding regions of the genome

By Roger P. Alexander, Gang Fang, Joel S. Rozowsky, Michael Snyder, Mark Gerstein. Nature reviews genetics, 2010

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How researchers see this paper

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Non-coding RNAs in human disease (2011, background): “5% of the genome, a proportion that increases to 2% if untranslated regions (UTRs) are considere”
Fast Identification and Removal of Sequence Contamination from Genomic and Metagenomic Datasets (2011, background): “For example, the operational definition of segmental duplications excludes ancient duplications that were formed by the same mechanisms long ago but that have since degraded below 90% sequence identity [39].”
A window into third-generation sequencing. (2010, methodology): “Not only can this technology be used to sequence DNA, but the DNA polymerase can be replaced with a reverse transcriptase enzyme to sequence RNA directly (29), without requiring the conversion of RNA to cDNA or without the need for ligation/amplification steps, something all existing SGS technologie”
Ultraconserved elements anchor thousands of genetic markers spanning multiple evolutionary timescales. (2012, background): “The function of UCEs is an active area of research (Alexander et al. 2010), and UCEs may be regulators and/or enhancers of gene expression (Woolfe et al.”