Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
By Miao-Chih Tsai, Ohad Manor, Yue Wan, N. Mosammaparast, Jordon K. Wang, F. Lan, Yang Shi, Eran Segal, Howard Y. Chang. Science, 2010
3,243 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/20644abac8f452c26b50ba98ee030fa58435cb27
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Howard Y. Chang
- Johannes Rinn
- Ling-Ling Chen
- David P. Bartel
- John S. Mattick
- Pedro J. Batista
- Richard A. Young
- Jeannie T. Lee
In Molecular Biology
- Howard Y. Chang
- Richard A. Young
- Johannes Rinn
- Ling-Ling Chen
- Aviv Regev
- David P. Bartel
- John S. Mattick
- Pedro J. Batista
Citations in the corpus
- Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB (2013, background): “In human cell lines, the HOTAIR lncRNA transcribed from the HOX C cluster inhibits transcription from HOX D cluster by guiding the recruitment of histone modifiers to specific chromatin in HOX D region [39,86,87].”
- Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “It seems that the lncRNA must serve two functions: (1) it must bind to a protein or protein complex, or at least facilitate the formation of a complex, perhaps acting as a scaffold [87]; and (2) the lncRNA must be able to target this complex to a specific DNA sequence.”
- The rise of regulatory RNA (2014, background): “…transformation in vivo 276 , Chang and colleagues also showed that lncRNAs could act as scaffolds for the assembly of histone modification complexes 277 , with the widespread alternative splicing of these RNAs suggesting that the cargo and/or target specificity can be varied in a context-dependent…”
- Control of Embryonic Stem Cell State (2011, background): “…complexes to the X-inactivation center X(ic), the kcnq1 domain, the INK4b/ARF/INK4a locus, the HOXD locus, andmany other genomic loci in ESCs and other cell types (Gupta et al., 2010; Pandey et al., 2008; Rinn et al., 2007; Tsai et al., 2010; Yap et al., 2010; Zhao et al., 2010; Zhao et al., 2008).”
- Long non-coding RNA (LncRNA) and cancer: a new paradigm (2017, background): “LSD1 interacts with corepressors REST and CoREST (54, 55).”
- Linking Long Noncoding RNA Localization and Function. (2016, background): “For instance, the interaction of nucleus-localized chromatin-modifying complexes with HOTAIR [21,22] and transcription factors with BCAR4 [25] may in turn keep these lncRNAs from nuclear export.”