Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study

By R. Whitmer, E. Gunderson, E. Barrett-Connor, C. Quesenberry, Kristine Yaffe. British medical journal, 2005

1,065 citations recorded by the source corpus.

Subfields: Physiology, Psychiatry and Mental health, Surgery

View Paper: https://www.semanticscholar.org/paper/a2cc2bba9c024739098d7b01486be7f29a130abb

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Citations in the corpus

Midlife and late-life obesity and the risk of dementia: cardiovascular health study. (2009, background): “High BMI in middle age has been found to be associatedwithhigherdementiarisk.(13,14) HigherBMIatages 70, 75, and 79 years has also been found to predict dementia,(17) although there have been reports of no association,(16) of lower BMI related to higher AD risk,(15) and of a U-shaped relation betwee”
Critical review: vegetables and fruit in the prevention of chronic diseases (2012, background): “increases the risk of dementia independent of comorbidities [277].”
Epidemiology of Alzheimer Disease (2012, positive): “…the association between elevated blood pressure during middle age and late-life cognitive impairment suggest that mid-life hypertension increases the risk of late-life dementia (Kilander et al. 2000; Launer et al. 2000; Wu et al. 2003; Yamada et al. 2003; Elias et al. 2004; Whitmer et al. 2005b).”
The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population (2006, background): “Because BMI is a surrogate index of body adiposity [9], direct indexes of adiposity such as skinfolds can be of value when studying the relationship between body fatness per se and disease [10,11].”
Body mass index in midlife and late‐life as a risk factor for dementia: a meta‐analysis of prospective studies (2011, background): “Despite reports of overweight BMI in midlife being a risk factor for dementia in late-life (10), some benefits of Abbreviations: AD, Alzheimer’s disease; APOE, Apolipoprotein E; BMI, body Mass Index; CI, confidence interval; MCI, mild cognitive impairment; MMSE, Mini Mental Status Examination; RR, r”
Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands (2010, positive): “Whether high fat feeding and obesity lead to activation of cdk5 in other non-adipose tissues is a very important question, since the negative effects of obesity extend far beyond the metabolic syndrome to cancer and neurodegeneration37,38.”