SOX2 functions to maintain neural progenitor identity.

By V. Graham, J. Khudyakov, P. Ellis, L. Pevny. Neuron, 2003

1,392 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a2c7770b72f3f213c255fffcc570b1ce0a48f522

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Citations in the corpus

TGFβ signalling: a complex web in cancer progression (2010, background): “Independently of this mechanism, TGFβ induces the expression of SOX2 , a self-renewal gene that helps to maintain stem cell-like properties in embryonic stem cells and neural stem cell”
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain (2004, background): “Sox (Sry-related HMG box) (Gubbay et al., 1990) genes encode transcription factors regulating crucial developmental decisions in different systems, such as early gonad, crystallin, chondrocytes and glia (Kamachi et al., 2000).”
The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, neutral): “Research on the Sox gene family began with the seminal discovery of the mammalian testis-determining factor, Sry (Gubbay et al., 1990; Sinclair et al., 1990).”
Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma (2016, positive): “The primary function of SOX2 in the nervous system is to promote self-renewal of neural stem cells and, within brain tumors, the glioma stem cell state (Graham et al., 2003).”
The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory (2008, background): “These stem cells are identified primarily by the expression of GFAP, accompanied by nestin or also Sox2 [8,10,43,44] and have been defined as type-1 cells [7].”
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis (2009, neutral): “and forced expression of Sox2 results in the loss of proneural cell”
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. (2007, background): “In the same context, Sox2 has been implicated in NSCs (Bylund et al., 2003; Ellis et al., 2004; Ferri et al., 2004; Graham et al., 2003; Taranova et al., 2006), but the question of whether Sox2 + cells in the SGZ possess the multipotent and self-renewing capacities has remained unsolved.”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “Sox2 is expressed in embryonic and adult stem cells, and functions to maintain neural stem cells in their undifferentiated state (Graham et al., 2003; Ferri et al., 2004).”
Mechanisms of stem cell self-renewal. (2009, background): “SoxB1 family proteins (including Sox1, 2, and 3) suppress neuronal differentiation and maintain neural stem cell identity during the neurogenic phase of cortical development, avoiding premature differentiation (Avilion et al. 2003, Graham et al. 2003).”