Sorting out the complexity of SR protein functions.

By Brenton R. Graveley. RNA: A publication of the RNA Society, 2000

1,165 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a279bffdb245385509e26075e2eab337895eecec

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In Molecular Biology

Citations in the corpus

Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. (2008, background): “Most ESEs function by recruiting members of the SR protein family (for review, see Graveley 2000).”
Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. (2006, background): “These motifs are classified as exonic or intronic splicing enhancers (ESE/ISE) and silencers (ESS/ISS), and they are required for the regulation of both constitutive and alternative splicing (Blencowe, 2000; Graveley, 2000).”
ESEfinder: a web resource to identify exonic splicing enhancers (2003, background): “Different SR proteins have different substrate specificities, and multiple classes of ESE consensus motifs have been described (3, 6, 7).”
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches (2009, background): “ESEs are usually bound by members of the SR (Ser–Arg) protein family”
Understanding alternative splicing: towards a cellular code (2005, background): “SR proteins have roles in several steps of spliceosome assembly, and function as both essential splicing factors and regulatory factor”
Negative Regulation of Active Zone Assembly by a Newly Identified SR Protein Kinase (2009, background): “The best-characterized role for SRPKs is in controlling the subcellular localization of SR proteins, thereby regulating their nuclear pre-mRNA splicing activity [12].”
An extensive network of coupling among gene expression machines (2002, neutral): “This family, which contains arginine/serine (RS) domain”
Nuclear Pre-mRNA Splicing in Plants (2001, background): “There is some evidence in animals that such intranuclear redistribution may also be controlled by phosphorylation of splicing factors (Duncan et al., 1997; Graveley, 2000; Smith and Valcarcel, 2000).”
Comprehensive proteomic analysis of the human spliceosome (2002, background): “Among these are all known canonical members of the SR family of splicing factor”