Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

By U. Senftleben, Yixue Cao, G. Xiao, F. Greten, G. Krähn, G. Bonizzi, Yi Chen, Yinling Hu, A. Fong, Shao-Cong Sun and 1 more. Science, 2001

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Modulation of NF-κB Activity by Exchange of Dimers (2003, background): “Release of p52/ RelB (Senftleben et al., 2001; Xiao et al., 2001) as wellIntroduction as p50/RelB dimers (Muller and Siebenlist, 2003) occurs through a “noncanonical” pathway requiring the NF- B-The nuclear factor kappa B (NF- B) family of transcripinducing kinase (NIK) (Xiao et al., 2001), which…”
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. (2007, background): “Equally remarkably, this treatment also caused a significant stabilization of NIK, the kinase that is required to activate noncanonical NF-kB, which is usually undetectable in cells (He et al., 2006; Senftleben et al., 2001).”
The NF-κB pathway (2005, background): “The latter phosphorylates p100, resulting in its polyubiquitinylation and processing to p52 (Senftleben et al., 2001).”
NF-kB in development and progression of human cancer (2005, background): “The dimers contain RelB and p100 subunits [60].ThispathwaymainlyactivatesIKKα,whichphosphorylates p100 that is subsequently proteolysed to generate the p52 mature form [17, 59 ].”