Modulation of NF-κB Activity by Exchange of Dimers

By S. Saccani, Serafino Pantano, G. Natoli. 2003

308 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/18ed1fc8811804095445453251029024fafd427f

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In Immunology

Citations in the corpus

Good cop, bad cop: the different faces of NF-κB (2006, background): “The composition of the NF-kB dimer can vary depending on cell type, the nature of the inducing stimulus or the time elapsed after initial exposure to the stimulus.(1,9,10) Given that NF-kB subunits are expressed in all cell types and there are hundreds of activators,(3) the number of different conte”
Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import 1 (2004, background): “The predominant cytosolic occurrence and short duration of p65 phosphorylation argue against a prominent role of this posttranslational modification for NF- B-dependent gene expression, which requires longer time periods (52).”
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. (2013, methodology): “Chromatin Immunoprecipitation Analysis ChIP assays were performed with antibodies against b-catenin, RelA/p65, and EGFR (negative control) according to published procedures (Saccani et al., 2003).”
Transcriptional regulation via the NF-κB signaling module (2006, background): “Intriguingly, RelB has been reported to have both positive and negative transcriptional activities (Saccani et al., 2003; Bonizzi et al., 2004; Jacque et al., 2005), but the molecular basis for alternate activities remains unknown.”
Sequence and chromatin determinants of cell-type–specific transcription factor binding (2012, background): “While differential binding due to complex composition has been observed previously at specific loci (van Dam and Castellazzi 2001; Saccani et al. 2003; Leung et al. 2004; So et al. 2007), we present the first genome-wide assessment of how these complexes may contribute to cell-type specificity.”
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island (2004, background): “Alternatively, other forms of transcriptionally active NF-κB complex (such as p50-p52) may be involve”
A physical and functional map of the human TNF-α/NF-κB signal transduction pathway (2004, background): “The specific chromatin components might explain the unique functions of RelB among the NF-κB family members in the activation of late response gene”
New regulators of NF-κB in inflammation (2008, background): “Induction of p100 expression by NF-κB can also facilitate the exchange of p65-containing heterodimers for heterodimers of RELB and p52 (Ref”