Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty.

By W. Ershler, E. Keller. Annual Review of Medicine, 2000

1,254 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Endocrinology, Diabetes and Metabolism, Immunology

View Paper: https://www.semanticscholar.org/paper/a249cad87eeeb95b3701b64939c61e37720c3521

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In Biological Psychiatry

In Endocrinology, Diabetes and Metabolism

In Immunology

Citations in the corpus

Immunity, Inflammation, and Cancer (2010, neutral): “Most solid malignancies appear in older individuals and even old age (Ershler and Keller, 2000) and cell senescence (Rodier et al., 2009) are postulated to be tumor promoters that act through inflammatory mechanisms.”
An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “In humans, IL-1 , IL-6, and TNF- are generally higher in the plasma of older individuals compared with their young counterparts (10, 37, 54, 61, 70, 202).”
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. (2002, methodology): “Our findings, along with recent studies detailing the relationship between elevated IL-6 level and the development of disability and early mortality in healthy older adults, provide supportive evidence for further etiologic studies.(13) Although we have no direct measurements of IL-6 or other inflam”
Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “IL-6 in particular has been directly associated with the development of age-related disorders, including osteoporosis, cognitive decline and frailty symptoms [114–117].”
The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. (2010, background): “Parasympathetic activity and HRV have been associated with immune dysfunction and inflammation, which have been implicated in a wide range of conditions including CVD, diabetes, osteoporosis, arthritis, Alzheimer's disease, periodontal disease, and certain types of cancers as well as declines in mus”
Age-related inflammatory cytokines and disease. (2003, background): “It has been suggested that the increased production of cytokines in healthy, older individuals results from the loss of sex steroids [43].”
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. (2007, background): “For instance, inflammation is associated with atherosclerosis (2, 3), diabetes (4), obesity (5), smoking-related illnesses (6), dementia (7), osteoporosis (8), and macular degeneration (9).”
Inflammatory markers in population studies of aging (2010, neutral): “Chronic low-grade inflammation has been related to frailty, its components and its outcomes in several studies (Ershler and Keller 2000; Hubbard, O'Mahony et al. 2009; Fulop, Larbi et al. 2010).”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “Indeed, CR has been shown to attenuate the age-related increase of systemic levels of several pro-inflammatory mediators (Ershler and Keller, 2000; Krabbe et al., 2004), such as TNF-α, IL-1β, IL-6, CRP and various AMs (Phillips and Leeuwenburgh, 2005; Kalani et al., 2006).”