Inflammatory markers in population studies of aging

By Tushar Singh, Anne B. Newman. Ageing Research Reviews, 2010

841 citations recorded by the source corpus.

Purpose To review findings from major epidemiologic studies regarding risk factors and consequences of elevated markers of inflammation in older adults. Results Most of the large, current epidemiologic studies of older adults have included serum interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-alpha), and some more extensive batteries of measures including soluble receptors. Few risk factors for the modest elevations seen with aging have been defined, including, visceral adiposity, lower sex steroid hormones, smoking, and depression. Of the markers assessed, IL-6 is most robustly associated with disease, disability and mortality. Conclusion IL-6 is a non-specific marker of adverse outcomes in older adults.

Subfields: Epidemiology, Periodontics, Physiology

View Paper: https://www.semanticscholar.org/paper/2cfbc62a204992e15a90c145556c9b53210bdf72

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In Epidemiology

1. Claudio Franceschi
2. Paolo Garagnani

In Physiology

1. Claudio Franceschi
2. Paolo Garagnani
3. M. Capri
4. S. Salvioli

Citations in the corpus

• Inflammaging and 'Garb-aging'. (2017, background): “Many epidemiological and biodemographic studies show that biomarkers of inflammation are robust predictors of morbidity (chronic diseases) and mortality in the elderly [1,2].”