Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study.

By J. Walston, M. McBurnie, Anne B. Newman, R. Tracy, W. Kop, C. Hirsch, J. Gottdiener, L. Fried. Archives of Internal Medicine, 2002

971 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/02cd5abaff302d9773e42a9f333d92d66df7c9a3

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Citations in the corpus

Frailty Syndrome: A Transitional State in a Dynamic Process (2009, methodology): “have demonstrated the varying ability to express different grades of frailty between several different models of frailty. Biological Markers of Frailty The Cardiovascular Health Study, using the currently recognized working definition of frailty, compared biological inflammatory markers between 29”
Frailty: an emerging research and clinical paradigm--issues and controversies. (2006, background): “For example, chronic inflammation is believed to play a central role in the pathogenesis of frailty (25,38).”
Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group (2013, neutral): “…both the risk of future physical and cognitive declines, such as inflammatory biomarkers [e.g. C-reactive protein (CrP) and interleukin-6 (il-6)] (28, 75, 76-78). however, biomarkers predictive of both types of decline may not be particularly useful in differentiating whether a person is at…”
Frailty: Emergence and Consequences in Women Aged 65 and Older in the Women's Health Initiative Observational Study (2005, background): “In the CHS, significantly higher BMI was reported in frail men and women studied cross-sectionally, and the paradox of this finding with low body weight and weight loss as a component for defining frailty was noted.(16) A quadratic relationship between body fat and strength in people aged 70 to 79 h”
A Comparison of Frailty Indexes for the Prediction of Falls, Disability, Fractures and Mortality in Older Men (2009, background): “The CHS index has also been linked to specific alterations in physiological and biological pathways that may lead to multisystem impairment underlying the development of the clinical frailty syndrome.(28) It has been suggested that the CHS index might serve as the basis for screening older persons f”