WNT and beta-catenin signalling: diseases and therapies.

By R. Moon, A. D. Kohn, G. V. De Ferrari, A. Kaykas. Nature reviews genetics, 2004

975 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a246516fb3ac6c3c90c374df82519a5d84d943d6

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1. R. Nusse
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Citations in the corpus

• Critical roles of SMYD2-mediated β-catenin methylation for nuclear translocation and activation of Wnt signaling (2017, background): “β-catenin functions as the transcriptional co-activator in the Wnt signaling pathway and transmits the signal by regulating the downstream genes including key developmental genes or those involved in development/progression of human cancer [1-5].”
• Towards an integrated view of Wnt signaling in development (2009, background): “For a number of years, the Wnt field focused on elucidating the biochemical mechanisms that control the activity of β-catenin/TCF (reviewed by Barker, 2008; Huang and He, 2008; Moon et al., 2004).”
• Potential Adverse Effects of Resveratrol: A Literature Review (2020, background): “A 450 mg/day dose of RE was reported to be a safe dose for a 60-kg person [184].”
• CRISPR-mediated direct mutation of cancer genes in the mouse liver (2014, unknown): “4a) that have been shown to abolish phosphorylation and cause stabilization and nuclear localization of β -Catenin 28 .”
• Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “The Wnt pathway plays an important role in cancer (Polakis, 2000; Moon et al., 2004) and thus it is not surprising that Wnt modulators, including Dkks, are also involved.”
• INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 (2014, unknown): “tankyrase inhibitors, secreted FZD-related proteins, Rspondin, Dickkopf1 (DKK1), Norrin and molecules targeting the co-receptors of the WNT/FZD pathway are being considered as putative drugs for diseases such as different types of cancer, neurodegenerative diseases and osteoporosis (Logan and Nusse,”
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, background): “stabilization and nuclear localization of this free pool are necessary for b-catenin as a coactivator of TCF-dependent transcription (Clevers, 2006; Klaus and Birchmeier, 2008; Logan and Nusse, 2004; Moon et al., 2004).”
• TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. (2006, background): “958 Cell 126, 955–968, September 8, 2006 ª2006 Elsevier Inc. Dishevelled-2 (Dvl-2) acts positively in Wnt signaling (Moon et al., 2004).”