Ferroptosis is an autophagic cell death process

By Minghui Gao, Prashant Monian, Qiuhui Pan, Wei Zhang, J. Xiang, Xuejun Jiang. Cell Research, 2016

1,645 citations recorded by the source corpus.

Subfields: Epidemiology, Hematology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/a1c5ce6b85f2df3984a97112cb267c1c4f59868a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Guido Kroemer
2. D. Tang
3. R. Kang
4. D. Klionsky
5. Craig B. Thompson
6. Brent R. Stockwell
7. Xin Chen
8. Peter Vandenabeele

In Hematology

1. D. Tang
2. Brent R. Stockwell

In Pulmonary and Respiratory Medicine

1. D. Tang
2. R. Kang
3. Guido Kroemer
4. Brent R. Stockwell
5. Xin Chen
6. Jiao Liu
7. Xuejun Jiang
8. D. Klionsky

Citations in the corpus

• The molecular machinery of regulated cell death (2019, positive): “Ferritinophagy causes ferroptosis due to the selective degradation of ferritin (an iron storage protein), consequently causing iron release and oxidative injury.(158,159) The degradation of protein tyrosine phosphatase, nonreceptor type 13 (PTPN13, a negative regulator of extrinsic apoptosis)(235) f”
• Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. (2017, neutral): “Selective autophagy of ferritin, referred to as ferritinophagy, modulates ferroptosis sensitivity, possibly by controlling iron availability (Gao et al., 2016; Hou et al., 2016; Mancias et al., 2014; Wang et al., 2016b).”
• Ferroptosis: mechanisms and links with diseases (2021, background): “Genetic and pharmacological inhibition of NCOA4 can protect cells from ferroptosis via reducing cellular labile iron.(9) Inhibition of lysosomal function, the endpoint of autophagy flux, can significantly block erastin-induced ferroptosis in both MEFs and HT1080 cells.”
• Copper metabolism in cell death and autophagy (2023, background): “For example, recent studies have highlighted that ferroptosis is a type of autophagy-dependent cell death due to autophagy-mediated degradation of antiferroptotic factors [178,179], such as ferritin [180,181], lipid droplets [182], GPX4 [152,183–185], or CDH2 (cadherin 2) [186].”
• The Development of the Concept of Ferroptosis (2018, neutral): “The importance of autophagy (specifically ‘ferritinophagy’) for inducing ferroptosis is demonstrated by the complete blockage of ferroptotic death by inhibition of NCOA4, a specific autophagy cargo receptor that mediated the delivery of ferritin to lysosomes [129].”