The molecular machinery of regulated cell death

By D. Tang, R. Kang, T. Vanden Berghe, Peter Vandenabeele, Guido Kroemer. Cell Research, 2019

2,188 citations recorded by the source corpus.

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/db5c07bfe28c35290f84480dcb7de884ab36c55f

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In Molecular Biology

1. D. Tang
2. Guido Kroemer
3. R. Kang
4. Xin Chen
5. D. Klionsky
6. Jiao Liu
7. Yan Yu
8. Weitong Gao

Citations in the corpus

• Copper induces cell death by targeting lipoylated TCA cycle proteins (2022, background): “Cell death involves signaling cascades and molecularly-defined effector mechanisms (20) involving proteins and lipids such as those characteristic of apoptosis (21), necroptosis (22), pyroptosis (23) and ferroptosis (24), which is a recently discovered iron-dependent cell death pathway.”
• Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options (2022, background): “Immunocyte apoptosis Apoptosis is a form of regulated cell death that aims to remove damaged cells and maintain homeostasis under physiological conditions [32].”
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “Based on different morphological, biochemical, immunological, and genetic characteristics, RCD is subdivided into apoptotic and non-apoptotic categories.(2,3) Non-apoptotic RCD can be subdivided into autophagy, ferroptosis, pyroptosis, and necroptosis (Table 1 and Fig.”
• Nanomedicine in cancer therapy (2023, background): “425 Therefore, permeabilizing lysosomal membranes of tumor cells using lysosome-targeted nanoparticles is an attractive therapeutic strategy.”
• Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “Cell membrane rupture that is associated with the breakdown of membrane lipids (phospholipids, glycolipids, and cholesterol) is the hallmark of regulated necrosis, including necroptosis, pyroptosis, alkaliptosis, and ferroptosis (Tang et al., 2019).”
• Regulated cell death (RCD) in cancer: key pathways and targeted therapies (2022, background): “Entosis is an RCD form of "cannibalism" of cells.(293) One cell engulfs and kills another cell, which is characterized by intracellular cell structure.”
• Hallmarks of neurodegenerative diseases. (2023, neutral): “114,139,140 Although different types of neuronal death exist, there is cross-talk between mechanisms, and it is possible that if a neuron does not execute a specific cell death program, another one might take over.”