Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo.

By Sanchita Bhatnagar, K. Shinagawa, F. Castellino, J. Schorey. Blood, 2007

627 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a1c4ce7c72800dd90d6e0e8883a49df19da389fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Prachi Singh
2. Yong Cheng
3. V. L. Smith
4. J. Schorey
5. A. Llorente
6. María Yáñez-Mó
7. Rong Xu
8. Richard J. Simpson

In Molecular Biology

1. Prachi Singh
2. Yong Cheng
3. V. L. Smith
4. Richard J. Simpson
5. E. Batrakova
6. A. Llorente
7. David W. Greening
8. J. Schorey

Citations in the corpus

• Extracellular vesicles in cancer: cell-to-cell mediators of metastasis (2016, background): “Since then, the role of EVs in immune regulation has been intensively studied and several mechanisms have been proposed for the release of exosomes carrying immunomodulatory molecules by various immune cells upon infection, which can influence primary and secondary immune responses (Admyre et al., 2”
• Exosomes as Drug Delivery Vehicles for Parkinson’s Disease Therapy (2015, background): “Regarding their nature, exosomes are nanosized vesicles secreted by a variety of cells [23], in particular, cells of the immune system: dendritic cells [24], macrophages [25], B cells [26], and T cells [27].”
• Exosome Function: From Tumor Immunology to Pathogen Biology (2008, background): “Interestingly, this phenomenon of immune surveillance in the host by exosomes was not unique to the Mycobacterium genus as exosomes isolated from Salmonella typhimurium- or Toxoplasma gondii-infected macrophages also stimulated a proinflammatory response in uninfected cells (72).”
• Exosomes and other extracellular vesicles in host–pathogen interactions (2014, positive): “In addition to mycobacteria, exosomes from Salmonella-infected macrophages are also pro-inflammatory, increasing TNF-a production by human monocytes (Fig 4) [10].”
• Exosomes and their roles in immune regulation and cancer. (2015, background): “Further, exosomes released from macrophages nfected with intracellular pathogens stimulate a pro-inflammatory esponse in vitro and in vivo [106].”
• Biological properties of extracellular vesicles and their physiological functions (2015, background): “bovis BCG had mycobacterial pathogenassociated molecular patterns (PAMPs) and were immune stimulatory (290).”
• Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, neutral): “For example, in monocytes and neutrophils, it is the P2X purinoreceptor activation by ATP, in platelets it is the thrombin receptor activation, and for bacterial lipopolysaccharide the toll-like receptor-4 on dendritic cells have been recognized [32, 33].”
• Using exosomes, naturally-equipped nanocarriers, for drug delivery (2015, background): “Exosomes are 40–100 nm sized extracellular membrane-derived vesicles actively secreted by most cell types, in particular, cells of the immune system such as dendritic cells [10], macrophages [14], B cells [15], and T cells [16]; as well as mesenchymal stem cells [17], endothelial [18] and epithelial”