A Strategy for Probing the Function of Noncoding RNAs Finds a Repressor of NFAT

By A. Willingham, A. Orth, S. Batalov, E. Peters, Ben G. Wen, P. Aza‐Blanc, John B. Hogenesch, Peter G. Schultz. Science, 2005

761 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a17de08571e3dd126875702234c0397935f0ca82

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Citations in the corpus

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “In light of the diversity and abundance of long ncRNAs, the functional characterization of this transcript class is a considerable challenge, and functional screens using cell-based assays have met with limited success (Willingham et al. 2005).”
An Architectural Role for a Nuclear Non-coding RNA: NEAT1 RNA is Essential for the Structure of Paraspeckles (2009, background): “For example, XIST RNA is involved in silencing the inactive X chromosome (Brockdorff and Duthie, 1998; Brown, 1991; Hall and Lawrence, 2003), NRON RNA regulates the nuclear trafficking of the NFAT protein (Willingham et al., 2005), and HOTAIR RNA represses HOX loci in trans (Rinn et al., 2007).”
MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. (2009, neutral): “7 kb (Willingham et al. 2005).”
Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction (2006, background): “Recently, Willingham et al. (2005) identified a functional long non-coding RNA (termed NRON), which acts as a repressor of the nuclear factor of activated T cell (NFAT), and showed that specific ncRNAs as NRON may play a role in regulating the complexity of intracellular trafficking.”
Genome-wide computational identification and manual annotation of human long noncoding RNA genes. (2010, background): “…database (H-InvDB) (Yamasaki et al. 2008), RNAdb (Pang et al. 2007), a human–mouse conserved lncRNA set used in a high-throughput functional screen (Willingham et al. 2005), and primate-specific ncRNAs stratified by sequence conservation and the probability of forming stable secondary structures…”
Genome-wide transcription and the implications for genomic organization (2007, background): “Long ncRNAs have also been directly linked to regulation of transcription factors such as calcium-sensing nuclear factor of activated T-cells ( NFAT”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “7 kb) (Willingham et al. 2005).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “In the case of suiting stimuli of the cell, NFAT dissociates from the complex, is dephosphorylated and shuttled into the nucleus, where its leads to the expression of NFAT-regulated genes (243, 289).”
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals (2009, neutral): “(1) Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge MA 02142 (2) Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139 (3) Department of Pathology, Beth Israel Deaconess Medical Center, Boston MA 02215 (4) Division of Health Sciences and Technology, Massa”
The rise of regulatory RNA (2014, background): “A substantial proportion of lncRNAs reside within, or are dynamically shuttled, to the cytoplasm indicating roles in other cellular processes, including the regulation of protein localization 293 , mRNA translation 294 and mRNA stability 295 .”