Evolution of protein kinase signaling from yeast to man.

By Gerard Manning, G. Plowman, T. Hunter, S. Sudarsanam. TIBS -Trends in Biochemical Sciences. Regular ed, 2002

976 citations recorded by the source corpus.

Subfields: Aging, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a16b946cbc2d746dd3d510a4efb88b1f5606327f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

J. Ferrell

In Genetics

In Molecular Biology

Citations in the corpus

FlyBase: establishing a Gene Group resource for Drosophila melanogaster (2015, background): “com (7), Ribosomal Protein Gene database (8)), or are organism-specific databases that include discrete lists of related genes (e.”
Tertiary alphabet for the observable protein structural universe (2016, background): “In particular, degeneracy at the level of domains, folds, and functional modules is likely strongly influenced by evolution, whereby such elements recur in different proteins often because of a common ancestor (18, 19).”
Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote (2006, neutral): “thermophila is perhaps best seen in the fact that 630 (approximately 60%) of the kinases could not be assigned to any known family or subfamily [105].”
Mapping pathways and phenotypes by systematic gene overexpression. (2006, background): “For example, the wiring diagrams of signaling pathways are largely incomplete ; there are hundreds of kinases and phosphatases in yeast (Manning et al., 2002) and very little is known about their targets, highlighting the need for new systematic genetic approaches.”
The Kinome of Pacific Oyster Crassostrea gigas, Its Expression during Development and in Response to Environmental Factors (2016, positive): “Analyses of mRNA expression levels of protein kinases has already been done in widely-studied organism from yeast to humans, offering insight into signaling in unicellular and multicellular organisms [16].”
Protein Kinases: Evolution of Dynamic Regulatory Proteins (2010, background): “This corresponds to nearly 2% of the entire genome and demonstrates the extraordinary importance of this family for regulating biological events [6].”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Remarkably, PI kinases surfaced earlier in evolution than tyrosine kinases (190, 986) with common ancestors being a group of serine-threonine kinases, called the PI-kinase related kinases (190, 669).”
Mechanisms of specificity in protein phosphorylation (2007, background): “It affects every basic cellular process, including metabolism, growth, division, differentiation, motility, organelle trafficking, membrane transport, muscle contraction, immunity, learning and memor”
Post-translational modifications in signal integration (2010, background): “5–2% of the entire protein-coding genes of eukaryote”