Traction Dynamics of Filopodia on Compliant Substrates

By Clarence E Chan, D. Odde. Science, 2008

834 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/a147f11ae9ba9850a6ebb5478177196ea40066f7

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In Atomic and Molecular Physics, and Optics

In Cell Biology

In Cellular and Molecular Neuroscience

Citations in the corpus

Integrin-mediated mechanotransduction (2016, background): “These molecules belong to the molecular clutch (see text box) that harnesses the power of the retrograde actin flow generated by the actin polymerization against the leading-edge cell membrane and the contractile actomyosin movements generated by nonmuscle myosin II to pull on FAs to propel the cell”
Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “Several models that address how cells respond to the mechanical properties of the ECM propose that rigidity determines how quickly forces act on the integrin–actin linkage”
Forces in tissue morphogenesis and patterning. (2013, positive): “Theoretical formulation and experimental data show that such coupling can lead to the emergence of oscillatory traction force (Chan and Odde, 2008).”
Physics of adherent cells (2013, background): “Indeed this irregular kind of motion has been observed for filopodia retraction and has been successfully simulated with a detailed stochastic model which also included the effect of stochastic force generation by myosin II motors (Chan and Odde, 2008).”
Actin dynamics, architecture, and mechanics in cell motility. (2014, background): “The response of filopodia to the mechanical stiffness of the local environment occurs through a motor-clutch mechanism (53).”
A photon-driven micromotor can direct nerve fibre growth (2011, neutral): “They not only sense the shape and size of the microstructure, but can also detect the elasticity of the substrat”
The biophysics of neuronal growth (2010, background): “3, in vitro, there are two different types of forces permanently exerted by neurons: tension along the neurite [61, 99, 109, 118] and contractile forces exerted by the growth cone [118, 127, 143].”
The trip of the tip: understanding the growth cone machinery (2009, background): “Studies show that filopodia function as points of attachment to the substrate and produce tension that is used for growth cone progressio”
Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “Recent computational and experimental work has shown that a dynamic slip clutch is a type of mechanosensor in which different ECM mechanics lead to very different force and adhesive behaviors (Chan & Odde 2008).”