The trip of the tip: understanding the growth cone machinery
By L. A. Lowery, David Van Vactor. Nature reviews. Molecular cell biology, 2009
823 citations recorded by the source corpus.
The central component in the road trip of axon guidance is the growth cone, a dynamic structure that is located at the tip of the growing axon. During its journey, the growth cone comprises both 'vehicle' and 'navigator'. Whereas the 'vehicle' maintains growth cone movement and contains the cytoskeletal structural elements of its framework, a motor to move forward and a mechanism to provide traction on the 'road', the 'navigator' aspect guides this system with spatial bias to translate environmental signals into directional movement. The understanding of the functions and regulation of the vehicle and navigator provides new insights into the cell biology of growth cone guidance.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/493f8844c557088bdcc1f23bf813ac01a3fcf7ae
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Citations in the corpus
- A photon-driven micromotor can direct nerve fibre growth (2011, background): “It is a highly motile structure that extends filopodia, which sense guidance cues, resulting in a cascade of intracellular signalling that ultimately affects the actin and microtubule cytoskeleton and causes the growth cone to turn towards or away from the guidance cue”
- The biophysics of neuronal growth (2010, background): “They also possess detectors of guidance cues that translate environmental cues into directional movement and thus guide the neuronal process in a spatially biased way toward their destination [15] (see section 2).”
- The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance (2011, background): “…for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 3Department of Cell and Developmental Biology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599 Correspondence: fgertler@mit.edu Axon outgrowth and guidance…”