Microbial ecology: Human gut microbes associated with obesity

By Ruth E. Ley, Peter J. Turnbaugh, S. Klein, Jeffrey I. Gordon. Nature, 2006

8,550 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/a12af92bd8887c424f432d27989bc2b224246d66

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Citations in the corpus

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa (2010, background): “The ratio of Firmicutes to Bacteroidetes differs in obese and lean humans, and this proportion decreases with weight loss on low-calorie diet (9).”
The Role of Microbial Amino Acid Metabolism in Host Metabolism (2015, background): “However, it should be noted that there have also been contradictory studies that did not find a shift in the Firmicutes-Bacteroidetes ratio [74,75].”
Role of microorganisms in the evolution of animals and plants: the hologenome theory of evolution. (2008, background): “In addition, it has been shown in mice (Ley et al., 2005; Turnbaugh et al., 2006) and humans (Ley et al., 2006b) that obesity is correlated with a higher proportion of microorganisms from the Bacteroidetes division as compared with those from the Firmicutes division.”
Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016, background): “lower levels of Bacteroidetes have been observed in obese individuals, and dietary intervention or bariatric surgery reverses these changes.(6)”
Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea (2009, background): “Many Firmicutes produce butyrate and are postulated to be involved in obesity in humans and murine models.(32,33) Short chain length fatty acids (SCFAs), especially butyrate, have also been shown to play a critical role in maintaining integrity of the colonic epithelium and regulation of the mucosal”
Fecal microbiota transplantation and emerging applications (2012, background): “Interestingly, comparisons between the distal gut microbiota of obese and lean individuals, as well as genetically obese and lean mice, have revealed differences in the distal gut microbiota composition and their metabolites”
Gut Microbiota in Cardiovascular Health and Disease (2017, background): “Initial animal and human studies supported associations between obesity and the higher ratio of Firmicutes to Bacteroidetes.36,91 In an intervention of calorie-restricted diets, weight loss was associated with decreases in Firmicutes to Bacteroidetes ratio both in low fat and low carbohydrate diets.”
Succession of microbial consortia in the developing infant gut microbiome (2010, background): “Adult microbiotas are thought to be relatively stable over time (14, 23, 24); this stability imparts resilience to disturbance, ensuring continued gut function.”
IgA response to symbiotic bacteria as a mediator of gut homeostasis. (2007, background): “How do perturbations in microbial ecology contribute to certain pathologic states such as infectious diarrheas, inflammatory bowel diseases, and metabolic abnormalities, for example (Frank et al., 2007; Ley et al., 2006b; Turnbaugh et al., 2006)?”