Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

By J. Teijaro, D. Turner, Quynh-Mai Pham, E. Wherry, L. Lefrançois, Donna L. Farber. Journal of Immunology, 2011

637 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a0bdb497ea2980b15112d6ad35f20c304da7efbb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Tissue-Resident Memory T Cells (2014, background): “These discrepancies were partly clarified upon the clear demonstration that populations of memory T cells were settled within many NLTs (Figure 1) (Gebhardt et al., 2009; Jiang et al., 2012; Masopust et al., 2010; Teijaro et al., 2011; Wakim et al., 2010).”
Human T cell development, localization, and function throughout life (2018, background): “…in diverse types of tissues including barrier sites, mucosal tissues, liver, salivary glands, and brain, where they are retained and do not recirculate as shown by parabiosis and in vivo labeling studies (Jiang et al., 2012; Mueller and Mackay, 2016; Steinert et al., 2015; Teijaro et al., 2011).”
Quantifying memory CD8 T cells reveals regionalization of immunosurveillance (2015, background): “These observations revise perceptions of immunosurveillance and may help explain why frontline memory CD8 T cell populations can rapidly detect infections in barrier tissues (Gebhardt et al., 2009; Jiang et al., 2012; Shin and Iwasaki, 2012; Teijaro et al., 2011; Wu et al., 2014).”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “Preferential homing of T cells into the lung has also been described (187, 188).”
Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets (2012, positive): “, 2011), althoughmouse memory T cells in spleen and LN are known to be CD69 (Casey et al., 2012; Teijaro et al., 2011).”
Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites (2017, background): “In mice, CD69 is expressed by the majority of CD4+ and CD8+ TRMs in multiple sites (Jiang et al., 2012; Masopust et al., 2006; Schenkel et al., 2013; Teijaro et al., 2011), while CD103 is only expressed by certain subsets of CD8+ TRM (Bergsbaken and Bevan, 2015; Mueller and Mackay, 2016) and not…”