Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

By Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Y. Nemoto, Tomohiro Mizutani, Xiu Zheng, S. Ichinose, T. Nagaishi, R. Okamoto, K. Tsuchiya and 2 more. Nature Medicine, 2012

598 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/a098aaed50f688770b15521875c78927c4596449

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. R. Nusse
3. Pengfei Lu

In Molecular Biology

1. Hans Clevers
2. Bonil Koo
3. Edwin Cuppen
4. Inha Heo
5. R. Nusse
6. Elaine Fuchs
7. C. Blanpain
8. M. Resh

In Oncology

1. Bonil Koo
2. Inha Heo
3. Hans Clevers
4. Pengfei Lu

Citations in the corpus

• The intestinal crypt, a prototype stem cell compartment. (2013, background): “The grafted organoids remained healthy and functional for at least 6 months after transplantation (Yui et al., 2012).”
• Stem Cell Organoid Engineering (2016, unknown): “Intestinal organoids have been transplanted into damaged colon for tissue repair (Yui et al., 2012), but only with limited engraftment success.”
• Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. (2013, background): “Successful transplantation of Cell clonal organoids derived from single Lgr5+ stem cells into damaged tissue has been demonstrated for mouse colon and liver, making the organoid system a promising tool for adult stem cell/gene therapy (Huch et al., 2013a; Yui et al., 2012).”
• Modeling Development and Disease with Organoids. (2016, background): “The organoids readily integrated as functional epithelial patches that were indiscernible from the surrounding host epithelium (Yui et al., 2012).”