Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

By A. Eden, F. Gaudet, A. Waghmare, R. Jaenisch. Science, 2003

1,440 citations recorded by the source corpus.

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In Molecular Biology

Citations in the corpus

Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, background): “Decreased methylation of repetitive sequences in the satellite DNA of the pericentric region of chromosomes is associated with increased chromosomal rearrangements, mitotic recombination, and aneuploidy (Eden et al., 2003; Karpf and Matsui, 2005).”
Cancer epigenetics reaches mainstream oncology (2011, background): “At repeat sequences, this is achieved by a higher rate of chromosomal rearrangements and, at retrotransposons, by a higher probability of translocation to other genomic region”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “In mice, DNA hypomethylation is sufficient to induce aggressive T-cell lymphomas with a high frequency of chromosome 15 trisomy (Eden et al., 2003; Gaudet et al., 2003), whereas tumor suppressor genes are usually silenced by site-specific DNA hypermethylation at their promoters (Esteller et al.”
DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. (2005, positive): “This epigenetic DNA modification affects gene expression and genome integrity (Eden et al., 2003) and is required for normal mouse development (Jackson-Grusby et al., 2001; Li et al., 1992).”
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. (2003, background): “Although inhibition of DNMT is expected to prevent hypermethylation, severe inhibition of DNMT activity, as suggested by recent genetic studies, may cause DNA hypomethylation, genomic instability, and early development of cancers such as T-cell lymphomas and sarcomas ( 40 , 41).”
Cancer epigenetics. (2005, background): “Enhanced tumorigenesis in Dnmt1 hypomorphic mice was shown to be related to increased chromosomal instability (179).”
DNA hypomethylation and human diseases. (2007, background): “DNMT3a and DNMT3b are believed to be primarily responsible for de novo methylation [122,123]; de novo methylation has been recorded at 3–5% per mitosis [20], enabling a change to occur in DNA methylation with time.”