Metabolism of inflammation limited by AMPK and pseudo-starvation

By L. O'Neill, D. Hardie. Nature, 2013

1,110 citations recorded by the source corpus.

Subfields: Cancer Research, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a039fb4d39bd67bc230346a033f0e918799e8963

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Erika L. Pearce
2. Guido Kroemer
3. L. Galluzzi
4. Russell G. Jones
5. M. Poffenberger
6. Douglas R. Green
7. Chih-Hao Chang
8. Edward J. Pearce

In Epidemiology

1. L. Galluzzi
2. Guido Kroemer
3. Douglas R. Green
4. Luke A. O'Neill
5. Edward J. Pearce
6. Mihai G. Netea
7. Jeong-a Kim
8. Hae-Suk Kim

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Douglas R. Green
4. G. Harry
5. Russell G. Jones
6. H. D. Alexander
7. H. Stunnenberg
8. I.Maeve Rea

Citations in the corpus

• Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013, background): “There is also a growing body of evidence implicating AMPK in the control of inflammation (3).”
• Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. (2015, background): “This phenotypic polarization of murine macrophages in response to their microenvironment is highly regulated at both transcriptional and metabolic levels (McGettrick and O’Neill, 2013; O’Neill and Hardie, 2013).”
• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity (2014, background): “This is in linewith observations that activatedmacrophages, dendritic cells, andTH1 and TH17 lymphocytes undergo a switch from oxidative phosphorylation to aerobic glycolysis (14).”
• Metabolic Pathways In Immune Cell Activation And Quiescence (2013, background): “Aspects of this area have been reviewed recently elsewhere (O’Neill and Hardie, 2013).”
• Microglial M1/M2 polarization and metabolic states (2016, background): “The majority of the published data on the bioenergetics of polarization states has been generated in peripheral immune cells (Biswas and Mantovani, 2012; O’Neill and Hardie, 2013; Pearce and Pearce, 2013) with only a few studies examining microglia (Moss and Bates, 2001; Chenais et al.”
• Pyruvate Kinase M2 regulates Hif-1α activity and IL-1β induction, and is a critical determinant of the Warburg Effect in LPS-activated macrophages (2015, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript INTRODUCTION Insights into the critical role of metabolic reprogramming in host defense and inflammation have recently emerged (Krawczyk et al., 2010; O’Neill and Hardie, 2013).”