Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
By Abhishek K. Jha, S. C. Huang, Alexey A. Sergushichev, Vicky Lampropoulou, Yulia Ivanova, Ekaterina Loginicheva, K. Chmielewski, Kelly M. Stewart, Juliet Ashall, B. Everts and 3 more. Immunity, 2015
1,792 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/247ba10bccd801d4373717864aa8a5dbc9b4856d
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In Immunology
- P. Murray
- Luke A. O'Neill
- Russell G. Jones
- Edward J. Pearce
- A. Viola
- F. Munari
- R. Sánchez-Rodríguez
- Tommaso Scolaro
In Molecular Biology
- Ping Gao
- Michael S. Diamond
- P. Murray
- Thomas Braun
- Russell G. Jones
- Eyal Gottlieb
- Wen Chen
- Yongsheng Li
Citations in the corpus
- The Metabolic Signature of Macrophage Responses (2019, methodology): “, CD206) abundantly expressed in M2 macrophages (32).”
- Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “80 Inhibiting mitochondrial fi ssion in LPS-activated macrophages with Mdivi-1, an antiDrp1 agonist, effectively reduces glycolytic reprogramming.”
- Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation (2018, background): “The glutamine seems to be fully required for IL-4 induction of macrophage alternative activation [120,121].”
- Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “Succinate has been shown to act as a proinflammatory metabolite that accumulates in LPS- or interferon-γ (IFN-γ)-treated macrophages (Tannahill et al., 2013; Jha et al., 2015).”
- Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation (2016, methodology): “Differentiation and Activation of Macrophages BMDM were prepared from 6- to 8-week-old mice as described (Jha et al., 2015) and seeded at 10(5) cells/well in 96-well tissue-culture plates in RMPI1640medium (ThermoFisher) supplementedwith 10%FBS, 2mML-glutamine (Thermo Fisher Scientific), and 100 U/m”
- Macrophage Polarization. (2017, background): “For example, glutamine is essential for M2 polarization, whereas M1 macrophages are glutamine independent, but the reasons remain unclear (89).”
- The role of macrophages in the resolution of inflammation. (2019, background): “The generation of these lipid mediators is consistent with an important role for macrophage metabolism in regulating tissue repair after injury (69, 70).”